Evaluation of HBV-Like Circulation in Wild and Farm Animals from Brazil and Uruguay

Yasmine R. Vieira, Moyra M. Portilho, Flávia F. Oliveira, Alexandro Guterres, Débora Regina L dos Santos, Lívia M. Villar, Santiago Mirazo, Juan Arbiza, Luana A.G. Dimache, Fernando Q. Almeida, Martha L. Brandão, José Luís P. Cordeiro, Fabiana L. Rocha, Fernanda C. Azevedo, Frederico G. Lemos, João Bosco V. Campos, Gabriel C. Macedo, Heitor M. Herrera, Igor Alexandre S. Péres, Namor P. Zimmermann, Ubiratan Piovezan, Aiesca O. Pellegrin, Vanessa S. de Paula and Marcelo A. Pinto
Additional contact information
Yasmine R. Vieira: Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
Moyra M. Portilho: Laboratório de Hepatites Virais, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
Flávia F. Oliveira: Laboratório de Virologia Molecular, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
Alexandro Guterres: Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
Débora Regina L dos Santos: Laboratório de Viroses Veterinárias, Departamento de Microbiologia Veterinária e Imunologia, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, RJ 23897-000, Brazil
Lívia M. Villar: Laboratório de Hepatites Virais, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
Santiago Mirazo: Sección Virología, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay
Juan Arbiza: Sección Virología, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay
Luana A.G. Dimache: Departamento de Medicina e Cirurgia, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, RJ 23897-000, Brazil
Fernando Q. Almeida: Departamento de Medicina e Cirurgia, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, RJ 23897-000, Brazil
Martha L. Brandão: Fiocruz Mata Atlântica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ 22713-560, Brazil
José Luís P. Cordeiro: Fiocruz Mata Atlântica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ 22713-560, Brazil
Fabiana L. Rocha: Centro de Ciências Aplicadas e Educação, Campus IV Litoral Norte, Universidade Federal da Paraíba, Rio Tinto, PB 58297-000, Brazil
Fernanda C. Azevedo: Programa de Conservação Mamíferos do Cerrado (PCMC), Cumari, GO 74690-900, Brazil
Frederico G. Lemos: Programa de Conservação Mamíferos do Cerrado (PCMC), Cumari, GO 74690-900, Brazil
João Bosco V. Campos: Laboratório de Biologia Parasitária, Universidade Católica Dom Bosco, Campo Grande, MS 79117-010, Brazil
Gabriel C. Macedo: Laboratório de Biologia Parasitária, Universidade Católica Dom Bosco, Campo Grande, MS 79117-010, Brazil
Heitor M. Herrera: Laboratório de Biologia Parasitária, Universidade Católica Dom Bosco, Campo Grande, MS 79117-010, Brazil
Igor Alexandre S. Péres: Embrapa Pantanal, CP 109, Corumbá, MS 79320-900, Brazil
Namor P. Zimmermann: Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil
Ubiratan Piovezan: Embrapa Tabuleiros Costeiros, Aracaju, SE 49040-490, Brazil
Aiesca O. Pellegrin: Embrapa Pantanal, CP 109, Corumbá, MS 79320-900, Brazil
Vanessa S. de Paula: Laboratório de Virologia Molecular, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
Marcelo A. Pinto: Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil

IJERPH, 2019, vol. 16, issue 15, 1-14

Abstract: The origin of the hepatitis B virus is a subject of wide deliberation among researchers. As a result, increasing academic interest has focused on the spread of the virus in different animal species. However, the sources of viral infection for many of these animals are unknown since transmission may occur from animal to animal, human to human, animal to human, and human to animal. The aim of this study was to evaluate hepadnavirus circulation in wild and farm animals (including animals raised under wild or free conditions) from different sites in Brazil and Uruguay using serological and molecular tools. A total of 487 domestic wild and farm animals were screened for hepatitis B virus (HBV) serological markers and tested via quantitative and qualitative polymerase chain reaction (PCR) to detect viral DNA. We report evidence of HBsAg (surface antigen of HBV) and total anti-HBc (HBV core antigen) markers as well as low-copy hepadnavirus DNA among domestic and wild animals. According to our results, which were confirmed by partial genome sequencing, as the proximity between humans and animals increases, the potential for pathogen dispersal also increases. A wider knowledge and understanding of reverse zoonoses should be sought for an effective One Health response.

Keywords: hepadnavirus; animal infectious diseases; disease impact; reverse zoonoses; real-time PCR (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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