The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism ( ANKK1 Taq1A ) and Personality Traits in Addicted Subjects

Anna Grzywacz, Jolanta Chmielowiec, Krzysztof Chmielowiec, Bożena Mroczek, Jolanta Masiak, Aleksandra Suchanecka, Olimpia Sipak-Szmigiel, Kamila Szumilas and Grzegorz Trybek
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Anna Grzywacz: Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland
Jolanta Chmielowiec: Department of Hygiene and Epidemiology, Faculty of Medicine and Health Science, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland
Krzysztof Chmielowiec: Department of Hygiene and Epidemiology, Faculty of Medicine and Health Science, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland
Bożena Mroczek: Department of Human Sciences in Medicine, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland
Jolanta Masiak: Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, 1 Aleje Racławickie St., 20-059 Lublin, Poland
Aleksandra Suchanecka: Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland
Olimpia Sipak-Szmigiel: Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland
Kamila Szumilas: Department of General Pathology, Pomeranian Medical University, Szczecin 70-111, Poland
Grzegorz Trybek: Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp. St., 70-111 Szczecin, Poland

IJERPH, 2019, vol. 16, issue 15, 1-13

Abstract: The Taq1A polymorphism located in the ANKK1 gene is one of the most widely studied polymorphisms in regards to the genetics of behavior and addiction. The aim of our study was to analyze this polymorphism with regard to personality characteristics and anxiety measured by means of the Personality Inventory—(NEO Five-Factor Inventory—NEO—FFI) and the State-Trait Anxiety Inventory (STAI) in polysubstance addicted subjects. The study group consisted of 600 male volunteers, including 299 addicted subjects and 301 controls. Psychiatrists recruited members for both groups. Addiction was diagnosed in the case group. In the control group mental illness was excluded. The same psychometric test and genotyping using the real-time PCR (polymerase chain reaction) method was performed for both groups. The results were investigated by means of multivariate analysis of the main effects Multi-factor ANOVA. Significantly higher scores on the scale of STAI state and Neuroticism and Openness traits, as well as lower scores on the scales of Extraversion, Agreeability, and Conscientiousness, were found in the case group subjects, compared to the controls. Differences in frequency of genotypes and alleles of Taq1A polymorphism between the studied groups were not found. Multi-factor ANOVA of addicted subjects and control subjects and the ANKK1 Taq1A variant interaction approximated the statistical significance for the STAI state. The main effects ANOVA of both subjects’ groups were found for the STAI state and trait, the Neuroticism scale, the Extraversion scale, and the Agreeability scale. The ANKK1 Taq1A main effects approximated the statistical significance of the STAI trait. Our study shows not only differences in personality traits between addicted and non-addicted subjects, but also the possible impact of ANKK1 on given traits and on addiction itself.

Keywords: addiction; polymorphism; personality traits; polysubstance use disorder (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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