Novel Insights into the Genetic Landscape of Nonalcoholic Fatty Liver Disease

Alice Emma Taliento, Marcello Dallio, Alessandro Federico, Daniele Prati and Luca Valenti
Additional contact information
Alice Emma Taliento: Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico IRCCS, 20122 Milan, Italy
Marcello Dallio: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy
Alessandro Federico: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy
Daniele Prati: Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico IRCCS, 20122 Milan, Italy
Luca Valenti: Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico IRCCS, 20122 Milan, Italy

IJERPH, 2019, vol. 16, issue 15, 1-13

Abstract: Nonalcoholic fatty liver disease (NAFLD), the most common liver disorder worldwide, is epidemiologically associated with overweight, insulin resistance features and type 2 diabetes, and can progress to advanced liver fibrosis and hepatocellular carcinoma. Genetic factors play an important role in the development of NAFLD, which is a multifactorial disease. Several common naturally occurring variants modulating lipid and retinol metabolism in hepatocytes predispose to NAFLD development and progression, in particular those in PNPLA3 , TM6SF2 , MBOAT7 , and HSD17B13 . In addition, genetic variants that protect hepatic cells from oxidative stress modulate the susceptibility to progressive NAFLD. Although the molecular mechanisms linking these genetic variants with liver disease are not yet fully understood, hepatic fat has emerged as a major driver of the disease, while altered retinol metabolism and mitochondrial oxidative stress play a role in determining the development of advanced NAFLD.

Keywords: liver; nonalcoholic fatty liver disease; hepatocellular carcinoma; steatosis; genetics; retinol; oxidative stress (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/16/15/2755/pdf (application/pdf)
https://www.mdpi.com/1660-4601/16/15/2755/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:16:y:2019:i:15:p:2755-:d:254034

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().