Treatment with 3-Aminobenzamide Negates the Radiofrequency-Induced Adaptive Response in Two Cell Models

Anna Sannino, Olga Zeni, Stefania Romeo, Maria Brigida Lioi and Maria Rosaria Scarfì
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Anna Sannino: Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy
Olga Zeni: Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy
Stefania Romeo: Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy
Maria Brigida Lioi: Department of Science, University of Basilicata, 85100 Potenza, Italy
Maria Rosaria Scarfì: Institute for Electromagnetic Sensing of the Environment (IREA), Italian National Research Council (CNR), 80124 Naples, Italy

IJERPH, 2019, vol. 16, issue 15, 1-7

Abstract: In previous investigations, we demonstrated that pre-exposure of different cell cultures to radiofrequency fields can reduce the damage induced by genotoxic agents, an effect resembling the so-called adaptive response. In this study, we pre-exposed human peripheral blood lymphocytes and Chinese hamster lung fibroblast cell line to 1950 MHz, UMTS (Universal Mobile Telecommunication System) signal, for 20 h, and then treated cultures with Mitomycin-C. After confirming the induction of an adaptive response in terms of the reduction of micronuclei formation, we observed that such a response was negated by treatments with 3-aminobenzamide. Since 3-aminobenzamide is an inhibitor of poly (ADP-ribose) polymerase enzyme, which is involved in DNA repair, these results support the possible involvement of DNA repair mechanisms in radiofrequency-induced adaptive response.

Keywords: radiofrequency; human lymphocytes; V79 cells; micronuclei; adaptive response; 3-aminobenzamide (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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