Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease

Marcello Dallio, Nadia Diano, Mario Masarone, Antonietta Gerarda Gravina, Vittorio Patanè, Mario Romeo, Rosa Di Sarno, Sonia Errico, Carla Nicolucci, Ludovico Abenavoli, Emidio Scarpellini, Luigi Boccuto, Marcello Persico, Carmelina Loguercio and Alessandro Federico
Additional contact information
Marcello Dallio: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Nadia Diano: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Mario Masarone: Department of Medicine and Surgery, University of Salerno, via Salvador Allende, 84081 Salerno, Italy
Antonietta Gerarda Gravina: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Vittorio Patanè: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Mario Romeo: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Rosa Di Sarno: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Sonia Errico: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Carla Nicolucci: Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Ludovico Abenavoli: Department of Health Sciences, University “Magna Graecia”, Viale Europa–Germaneto, 88110 Catanzaro, Italy
Emidio Scarpellini: Division of Gastroenterology, Department of Internal Medicine, TARGID, University Hospital Gasthuisberg, 3000 Leuven, Belgium
Luigi Boccuto: Greenwood Genetic Center, 113 Gregor Mendel Circle, Greenwood, SC 29646, USA
Marcello Persico: Department of Medicine and Surgery, University of Salerno, via Salvador Allende, 84081 Salerno, Italy
Carmelina Loguercio: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy
Alessandro Federico: Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, via Pansini 5, 80131 Naples, Italy

IJERPH, 2019, vol. 16, issue 17, 1-16

Abstract: Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preventive strategies. Endocrine disruptors (EDCs) in general, and bisphenol A (BPA) in particular, are a heterogeneous group of substances, largely distributed in daily use items, able to interfere with the normal signaling of several hormones that seem to be related to type 2 diabetes mellitus (T2DM), obesity, and other metabolic disorders. It is reasonable to hypothesize a BPA involvement in the pathogenesis and evolution of NAFLD. However, its mechanisms of action as well as its burden in the vicious circle that connects obesity, T2DM, metabolic syndrome, and NAFLD still remain to be completely defined. In this review we analyzed the scientific evidence on this promising research area, in order to provide an overview of the harmful effects linked to the exposure to EDCs as well as to frame the role that BPA would have in all phases of NAFLD evolution.

Keywords: bisphenol A; endocrine-disrupting compounds; oxidative stress; non-alcoholic fatty liver disease; hepatocellular carcinoma (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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