Exposure to Dental Filling Materials and the Risk of Dementia: A Population-Based Nested Case Control Study in Taiwan

Natalia Mikhailichenko, Kimitoshi Yagami, Jeng-Yuan Chiou, Jing-Yang Huang, Yu-Hsun Wang, James Cheng-Chung Wei and Te-Jen Lai
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Natalia Mikhailichenko: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Kimitoshi Yagami: Graduate School of Oral Medicine, Department of Oral Health Promotion, Matsumoto Dental University, 1780, Gobara, Hirooka, Shiojiri, Nagano 399-0781, Japan
Jeng-Yuan Chiou: School of Health Policy and Management, Chung Shan Medical University, Taichung 40201, Taiwan
Jing-Yang Huang: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
Yu-Hsun Wang: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
James Cheng-Chung Wei: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Te-Jen Lai: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

IJERPH, 2019, vol. 16, issue 18, 1-11

Abstract: When studying the range of toxic substances triggering dementia, special attention should be paid to the materials used in dental practice, particularly to dental fillings containing amalgam. This necessitated conducting large-scale epidemiologic studies. The aim of our research was to determine the risk factors for developing dementia when filling materials containing amalgam are used in dental practice. In order to achieve the set goals, the following tasks were undertaken: (1) The social and demographic characteristics of the examined patients were studied; (2) the spectrum of concomitant somatic diseases was determined in patients of different gender and age; and (3) the relationship between dementia incidence and the volume of dental filling material containing amalgam was identified in patients with different somatic diseases. In general, the research conducted did not reveal any direct relationship between the development of dementia and the volume of filling material containing amalgam. However, among the people with dementia, there were persons for whom its progression was accelerated in cases where a large volume of dental filling material containing amalgam was present.

Keywords: dementia; amalgam; dental fillings; advanced age; nested case control study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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