The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand

Warathit Semmarath, Mathuramat Seesen, Supachai Yodkeeree, Ratana Sapbamrer, Pisittawoot Ayood, Rungnapa Malasao, Penprapa Siviroj and Pornngarm Limtrakul (Dejkriengkraikul)
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Warathit Semmarath: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Mathuramat Seesen: Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Supachai Yodkeeree: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Ratana Sapbamrer: Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Pisittawoot Ayood: Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Rungnapa Malasao: Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Penprapa Siviroj: Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Pornngarm Limtrakul (Dejkriengkraikul): Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

IJERPH, 2019, vol. 16, issue 18, 1-15

Abstract: Thailand has officially reached the status of an “aged society” and become the developing country with the 2nd largest proportion of senior citizens in Southeast Asia. A cross-sectional study of 526 early-old community dwellers was conducted for the Fried frailty phenotype assessment, This included five indicators: Weakness, slowness, physical activity, exhaustion, and weight loss. C-reactive protein (CRP), interleukin-6 (IL-6), insulin-like growth factor-1, and CD4+:CD8+ Ratio which serve as blood-based biomarkers of frailty. The prevalence of frailty and pre-frail in this population was found to be 15% and 69.6% respectively and was higher among women than men. Frail ( n = 58) and non-frail ( n = 60) participants were evaluated for the associations between the frail indicators and the blood-based biomarkers. Serum levels of IL-6 and CRP from frail group were significantly elevated when compared with the non-frail counterparts ( p = 0.044 and 0.033, respectively), and were significantly associated with the frailty status with an Odd Ratio IL-6 [OR] of 1.554-fold (95% confidence interval [CI], 1.229–1.966) and an OR CRP of 1.011-fold (95 CI, 1.006–1.016). Decreased hand-grip strength was the only frailty indicator that was significantly associated with both inflammatory biomarkers, (OR IL-6 of 1.470-fold and OR CRP of 1.008-fold). Our study is the first to assess the frailty status among the early-old population in Thailand. These findings will encourage general practitioners to combine frailty indicators and serum biomarkers as early detection tools for at-risk older adults to achieve the goal of healthy aging.

Keywords: aging; frailty; fried’s phenotypes; frailty biomarkers; C-reactive protein; interleukin-6; cross-sectional study; Thailand (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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