New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease

Airton Cunha Martins, Patricia Morcillo, Omamuyovwi Meashack Ijomone, Vivek Venkataramani, Fiona Edith Harrison, Eunsook Lee, Aaron Blaine Bowman and Michael Aschner
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Airton Cunha Martins: Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Patricia Morcillo: Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Omamuyovwi Meashack Ijomone: Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology Akure, Akure 340252, Nigeria
Vivek Venkataramani: Department of Hematology and Medical Oncology and Institute of Pathology, University Medical Center Göttingen (UMG), 37075 Göttingen, Germany
Fiona Edith Harrison: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Eunsook Lee: Department of Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32301, USA
Aaron Blaine Bowman: School of Health Sciences, Purdue University, West Lafayette, IN 47907-2051, USA
Michael Aschner: Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA

IJERPH, 2019, vol. 16, issue 19, 1-16

Abstract: Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.

Keywords: manganese; Alzheimer’s disease; Parkinson’s disease; neurodegeneration (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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