Characterization of Chromosome-Mediated Bla OXA-894 in Shewanella xiamenensis Isolated from Pig Wastewater

Huiyun Zou, Ziyu Zhou, Huiyu Xia, Qian Zhao and Xuewen Li
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Huiyun Zou: Department of environment and health, School of Public Health, Shandong University, Jinan 250012, China
Ziyu Zhou: Department of environment and health, School of Public Health, Shandong University, Jinan 250012, China
Huiyu Xia: Department of environment and health, School of Public Health, Shandong University, Jinan 250012, China
Qian Zhao: Department of environment and health, School of Public Health, Shandong University, Jinan 250012, China
Xuewen Li: Department of environment and health, School of Public Health, Shandong University, Jinan 250012, China

IJERPH, 2019, vol. 16, issue 19, 1-7

Abstract: A new variant of the bla OXA-546 gene, namely bla OXA-894 , was identified on the chromosome of Shewanella xiamenensis isolated from pig wastewater in rural China. OXA-894 differs from OXA-546 (A46V, I219 del ) and OXA-48 (T167I, I219 del ) with two amino acid substitutions, respectively. The isolate was resistant to ampicillin, aztreonam, imipenem, meropenem and fosfomycin. Carba NP test confirmed S. xiamenensis strain sx20 as a carbapenemase-producer. The bla OXA-894 gene was located between the gene encoding a LysR family transcriptional regulator and the C15 gene. Its gene environment was similar to other S. xiamenensis with chromosome-located bla OXA-48 -like genes. The T24H and T94V amino acid substitutions of LuxS protein were predicted to be deleterious, which may affect the virulence phenotype. The occurrence and potential health risk of carbapenem-resistant S. xiamenensis in a water environment is of concern.

Keywords: bla OXA-894; Shewanella xiamenensis; genetic environment; pig wastewater (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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