Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations

Ana Villaverde-Hueso, Germán Sánchez-Díaz, Francisco J. Molina-Cabrero, Elisa Gallego, Manuel Posada de la Paz and Verónica Alonso-Ferreira
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Ana Villaverde-Hueso: Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain
Germán Sánchez-Díaz: Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain
Francisco J. Molina-Cabrero: Department of Preventive Medicine, Complejo Hospitalario Universitario de Albacete, 02006 Albacete, Spain
Elisa Gallego: Department of Preventive Medicine, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain
Manuel Posada de la Paz: Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain
Verónica Alonso-Ferreira: Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III, 28029 Madrid, Spain

IJERPH, 2019, vol. 16, issue 1, 1-12

Abstract: The aim of this study is to analyze population-based mortality attributed to cystic fibrosis (CF) over 36 years in Spain. CF deaths were obtained from the National Statistics Institute, using codes 277.0 from the International Classification of Diseases (ICD) ninth revision (ICD9-CM) and E84 from the tenth revision (ICD10) to determine the underlying cause of death. We calculated age-specific and age-adjusted mortality rates, and time trends were assessed using joinpoint regression. The geographic analysis by district was performed by standardized mortality ratios (SMRs) and smoothed-SMRs. A total of 1002 deaths due to CF were identified (50.5% women). Age-adjusted mortality rates fell by −0.95% per year between 1981 and 2016. The average age of death from CF increased due to the annual fall in the mortality of under-25s (−3.77% males, −2.37% females) and an increase in over-75s (3.49%). We identified districts with higher than expected death risks in the south (Andalusia), the Mediterranean coast (Murcia, Valencia, Catalonia), the West (Extremadura), and the Canary Islands. In conclusion, in this study we monitored the population-based mortality attributed to CF over a long period and found geographic differences in the risk of dying from this disease. These findings complement the information provided in other studies and registries and will be useful for health planning.

Keywords: cystic fibrosis; population-based mortality; mortality trends; geographic analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:16:y:2019:i:1:p:119-:d:194929

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