The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study

Zhiyuan Cheng, Ning Cheng, Dian Shi, Xiaoyu Ren, Ting Gan, Yana Bai and Kehu Yang
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Zhiyuan Cheng: Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
Ning Cheng: Centre of Medical Laboratory, School of Basic Medical Science, Lanzhou University, Lanzhou 730000, China
Dian Shi: School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China
Xiaoyu Ren: School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China
Ting Gan: School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China
Yana Bai: School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China
Kehu Yang: Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

IJERPH, 2019, vol. 16, issue 1, 1-15

Abstract: Background : Occupational nickel exposure can cause DNA oxidative damage and influence DNA repair. However, the underlying mechanism of nickel-induced high-risk of lung cancer has not been fully understood. Our study aims to evaluate whether the nickel-induced oxidative damage and DNA repair were correlated with the alterations in Smad2 phosphorylation status and Nkx2.1 expression levels, which has been considered as the lung cancer initiation gene. Methods : 140 nickel smelters and 140 age-matched administrative officers were randomly stratified by service length from Jinchang Cohort. Canonical regression, χ 2 test, Spearman correlation etc. were used to evaluate the association among service length, MDA, 8-OHdG, hOGG1, PARP, pSmad2, and Nkx2.1. Results : The concentrations of MDA, PARP, pSmad2, and Nkx2.1 significantly increased. Nkx2.1 ( r s = 0.312, p < 0.001) and Smad2 phosphorylation levels ( r s = 0.232, p = 0.006) were positively correlated with the employment length in nickel smelters, which was not observed in the administrative officer group. Also, elevation of Nkx2.1 expression was positively correlated with service length, 8-OHdG, PARP, hOGG1 and pSmad2 levels in nickel smelters. Conclusions : Occupational nickel exposure could increase the expression of Nkx2.1 and pSmad2, which correlated with the nickel-induced oxidative damage and DNA repair change.

Keywords: nickel smelters; Nkx2.1; pSmad2; oxidative stress; DNA repair (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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