The Effect of Silver Nanoparticles on Learning, Memory and Social Interaction in BALB/C Mice

Khaled Greish, Abdulelah Abdullah Alqahtani, Abdulla Falah Alotaibi, Ahmed Mohamed Abdulla, Aysha Tariq Bukelly, Fanar Mohammed Alsobyani, Ghazi Hamad Alharbi, Israa Saeed Alkiyumi, Majed Mutlaq Aldawish, Turki Fahad Alshahrani, Valeria Pittalà, Sebastien Taurin and Amer Kamal
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Khaled Greish: Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Abdulelah Abdullah Alqahtani: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Abdulla Falah Alotaibi: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Ahmed Mohamed Abdulla: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Aysha Tariq Bukelly: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Fanar Mohammed Alsobyani: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Ghazi Hamad Alharbi: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Israa Saeed Alkiyumi: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Majed Mutlaq Aldawish: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Turki Fahad Alshahrani: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Valeria Pittalà: Department of Drug Sciences, University of Catania, 95125 Catania, Italy
Sebastien Taurin: Department of Molecular Medicine, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Kingdom of Bahrain
Amer Kamal: Department of Physiology, Arabian Gulf University, Manama 329, Kingdom of Bahrain

IJERPH, 2019, vol. 16, issue 1, 1-10

Abstract: Silver Nanoparticles (AgNPs), an epitome of nanotechnology, appear in everyday products such as water filters, printer ink, toothpaste, food packaging and cosmetics mostly due to their bactericidal properties. Given this high level of public exposure, the safety of AgNPs has never been fully established. The unsafe use of AgNPs could pose a real threat, not only to public health but also to economic growth in many industries. In this paper, we tested the effect of AgNPs on memory, learning, social behaviour and motor function of BALB/C mice. Outcomes of the present study suggested an impairment of these functions in AgNPs treated groups. Overall, obtained data support the evidence that the systemic exposure to AgNPs may result in alteration of the cerebral cognition and warrants further consideration on the impact of the AgNPs on human health with respect to their potential neurotoxicity.

Keywords: silver nanoparticles; BALB/C mice; behavioural testing; nanotoxicity; learning; memory (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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