Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health: Design of SEPAGES Couple-Child Cohort

Sarah Lyon-Caen, Valérie Siroux, Johanna Lepeule, Philippe Lorimier, Pierre Hainaut, Pascal Mossuz, Joane Quentin, Karine Supernant, David Meary, Laurence Chaperot, Sam Bayat, Flemming Cassee, Sarah Valentino, Anne Couturier-Tarrade, Delphine Rousseau-Ralliard, Pascale Chavatte-Palmer, Claire Philippat, Isabelle Pin, Rémy Slama and The SEPAGES Study Group
Additional contact information
Sarah Lyon-Caen: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Valérie Siroux: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Johanna Lepeule: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Philippe Lorimier: Biological Ressources Centre (CRB), Grenoble University Hospital, 38700 La Tronche, France
Pierre Hainaut: Inserm, CNRS, Team of Tumor Molecular Pathology and Biomarkers, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Pascal Mossuz: Biological Ressources Centre (CRB), Grenoble University Hospital, 38700 La Tronche, France
Joane Quentin: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Karine Supernant: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
David Meary: CNRS, LPNC UMR 5105, University Grenoble Alpes, 38000 Grenoble, France
Laurence Chaperot: Inserm, CNRS, Team of Immunobiology and Immunotherapy in Chronic Diseases, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Sam Bayat: Pediatric Department, Grenoble University Hospital, 38700 La Tronche, France
Flemming Cassee: National Institute for Public Health and the Environment, 3720 Bilthoven, The Netherlands
Sarah Valentino: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350 Jouy-en-Josas, France
Anne Couturier-Tarrade: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350 Jouy-en-Josas, France
Delphine Rousseau-Ralliard: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350 Jouy-en-Josas, France
Pascale Chavatte-Palmer: UMR BDR, INRA, ENVA, Université Paris Saclay, 78350 Jouy-en-Josas, France
Claire Philippat: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Isabelle Pin: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
Rémy Slama: Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB (Institute for Advanced Biosciences) Joint Research Center, University Grenoble Alpes, 38700 Grenoble, France
The SEPAGES Study Group: Membership of the SEPAGES study group is provided in the Acknowledgements.

IJERPH, 2019, vol. 16, issue 20, 1-29

Abstract: In humans, studies based on Developmental Origins of Health and Disease (DOHaD) concept and targeting short half-lived chemicals, including many endocrine disruptors, generally assessed exposures from spot biospecimens. Effects of early-life exposure to atmospheric pollutants were reported, based on outdoor air pollution levels. For both exposure families, exposure misclassification is expected from these designs: for non-persistent chemicals, because a spot biospecimen is unlikely to capture exposure over windows longer than a few days; for air pollutants, because indoor levels are ignored. We developed a couple-child cohort relying on deep phenotyping and extended personal exposure assessment aiming to better characterize the effects of components of the exposome, including air pollutants and non-persistent endocrine disruptors, on child health and development. Pregnant women were included in SEPAGES couple-child cohort (Grenoble area) from 2014 to 2017. Maternal and children exposure to air pollutants was repeatedly assessed by personal monitors. DNA, RNA, serum, plasma, placenta, cord blood, meconium, child and mother stools, living cells, milk, hair and repeated urine samples were collected. A total of 484 pregnant women were recruited, with excellent compliance to the repeated urine sampling protocol (median, 43 urine samples per woman during pregnancy). The main health outcomes are child respiratory health using early objective measures, growth and neurodevelopment. Compared to former studies, the accuracy of assessment of non-persistent exposures is expected to be strongly improved in this new type of birth cohort tailored for the exposome concept, with deep phenotyping and extended exposure characterization. By targeting weaknesses in exposure assessment of the current approaches of cohorts on effects of early life environmental exposures with strong temporal variations, and relying on a rich biobank to provide insight on the underlying biological pathways whereby exposures affect health, this design is expected to provide deeper understanding of the interplay between the Exposome and child development and health.

Keywords: DOHaD; environmental epidemiology; birth cohort; endocrine disruptors; atmospheric pollutants; exposome; child health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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