Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India

Ramadass Balamurugan, Srinivasan Pugazhendhi, Gowri M. Balachander, Tamilselvan Dharmalingam, Elissa K Mortimer, Geetha L. Gopalsamy, Richard J. Woodman, Rosie Meng, David H. Alpers, Mark Manary, Henry J. Binder, Ian L. Brown, Graeme P. Young and Balakrishnan S. Ramakrishna
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Ramadass Balamurugan: Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India
Srinivasan Pugazhendhi: Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India
Gowri M. Balachander: Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India
Tamilselvan Dharmalingam: Wellcome Research Unit (Biochemistry), Christian Medical College, Vellore, Tamil Nadu 632004, India
Elissa K Mortimer: College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia
Geetha L. Gopalsamy: College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia
Richard J. Woodman: College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia
Rosie Meng: College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia
David H. Alpers: Washington University School of Medicine, Saint Louis, MO 63110, USA
Mark Manary: Washington University School of Medicine, Saint Louis, MO 63110, USA
Henry J. Binder: Yale University School of Medicine, New Haven, CT 06510, USA
Ian L. Brown: Australian Cancer Research Foundation, Sydney 2000, Australia
Graeme P. Young: College of Medicine and Public Health, Flinders University of South Australia, Bedford Park 5045, South Australia, Australia
Balakrishnan S. Ramakrishna: Department of Gastroenterology, Christian Medical College, Vellore, Tamil Nadu 632004, India

IJERPH, 2019, vol. 16, issue 20, 1-12

Abstract: The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted (‘healthy’) children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. At entry, stunted children had lower SCFA concentrations compared to healthy children. Both types of RS led to a significant decrease in fecal pH and increase in fecal acetate and propionate in both healthy and stunted children. However, while HAMS increased fecal butyrate in both groups of children, HAMSA increased butyrate in healthy but not stunted children. Furthermore, healthy children showed a significantly greater increase than stunted children in both acetate and butyrate when fed either RS. No adverse effects were reported with either RS. Stunted children have impaired capacity to ferment certain types of RS which has implications for choice of RS in formulations aimed at improving microbial function in stunted children.

Keywords: gut microbiota; colonic microbiota; human health; dysbiosis; therapeutic strategies; prebiotic; resistant starch (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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