Urban Air Pollution Particulates Suppress Human T-Cell Responses to Mycobacterium Tuberculosis

Olufunmilola Ibironke, Claudia Carranza, Srijata Sarkar, Martha Torres, Hyejeong Theresa Choi, Joyce Nwoko, Kathleen Black, Raul Quintana-Belmares, Álvaro Osornio-Vargas, Pamela Ohman-Strickland and Stephan Schwander
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Olufunmilola Ibironke: Physiology and Integrative Biology, Rutgers University, Piscataway, NJ 08854, USA
Claudia Carranza: Department of Microbiology, National Institute of Respiratory Diseases (INER), Mexico City 1408, Mexico
Srijata Sarkar: Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA
Martha Torres: Department of Microbiology, National Institute of Respiratory Diseases (INER), Mexico City 1408, Mexico
Hyejeong Theresa Choi: Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA
Joyce Nwoko: Department of Environmental and Occupational Health, Rutgers School of Public Health, Piscataway, NJ 08854, USA
Kathleen Black: Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA
Raul Quintana-Belmares: Instituto Nacional de Cancerología, Mexico City 1408, Mexico
Álvaro Osornio-Vargas: Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada
Pamela Ohman-Strickland: Department of Biostatistics Rutgers University School of Public Health, Piscataway, NJ 08854, USA
Stephan Schwander: Environmental and Occupational Health Sciences Institute, Rutgers, Piscataway, NJ 08854, USA

IJERPH, 2019, vol. 16, issue 21, 1-18

Abstract: Tuberculosis (TB) and air pollution both contribute significantly to the global burden of disease. Epidemiological studies show that exposure to household and urban air pollution increase the risk of new infections with Mycobacterium tuberculosis (M.tb) and the development of TB in persons infected with M.tb and alter treatment outcomes. There is increasing evidence that particulate matter (PM) exposure weakens protective antimycobacterial host immunity. Mechanisms by which exposure to urban PM may adversely affect M.tb -specific human T cell functions have not been studied. We, therefore, explored the effects of urban air pollution PM 2.5 (aerodynamic diameters ≤2.5µm) on M.tb-specific T cell functions in human peripheral blood mononuclear cells (PBMC). PM 2.5 exposure decreased the capacity of PBMC to control the growth of M.tb and the M.tb-induced expression of CD69, an early surface activation marker expressed on CD3 + T cells. PM 2.5 exposure also decreased the production of IFN-γ in CD3 + , TNF-α in CD3 + and CD14 + M.tb-infected PBMC, and the M.tb-induced expression of T-box transcription factor TBX21 (T-bet). In contrast, PM 2.5 exposure increased the expression of anti-inflammatory cytokine IL-10 in CD3 + and CD14 + PBMC. Taken together, PM 2.5 exposure of PBMC prior to infection with M.tb impairs critical antimycobacterial T cell immune functions.

Keywords: M.tb; PM 2.5; immunity; proinflammatory cytokines; T-bet (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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