Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs

Wojciech Wołyniec, Katarzyna Kasprowicz, Joanna Giebułtowicz, Natalia Korytowska, Katarzyna Zorena, Maria Bartoszewicz, Patrycja Rita-Tkachenko, Marcin Renke and Wojciech Ratkowski
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Wojciech Wołyniec: Department of Occupational, Metabolic and Internal Medicine, Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, 81-519 Gdynia, Poland
Katarzyna Kasprowicz: Department of Biology, Ecology and Sports Medicine, Gdańsk University of Physical Education and Sport, 80-336 Gdańsk, Poland
Joanna Giebułtowicz: Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
Natalia Korytowska: Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
Katarzyna Zorena: Department of Immunobiology and Environment Microbiology, Medical University of Gdańsk, 81-519 Gdynia, Poland
Maria Bartoszewicz: Department of Immunobiology and Environment Microbiology, Medical University of Gdańsk, 81-519 Gdynia, Poland
Patrycja Rita-Tkachenko: Medical Laboratories Bruss Group ALAB, Gdynia, Poland 81-519 Gdynia, Poland
Marcin Renke: Department of Occupational, Metabolic and Internal Medicine, Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, 81-519 Gdynia, Poland
Wojciech Ratkowski: Department of Athletics, Department of Athletics, Gdańsk University of Physical Education and Sport; 80-336 Gdańsk, Poland

IJERPH, 2019, vol. 16, issue 21, 1-19

Abstract: Acute kidney injury (AKI) is described as a relatively common complication of exercise. In clinical practice the diagnosis of AKI is based on serum creatinine, the level of which is dependent not only on glomerular filtration rate but also on muscle mass and injury. Therefore, the diagnosis of AKI is overestimated after physical exercise. The aim of this study was to determine changes in uremic toxins: creatinine, urea, uric acid, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), trimethylamine N-oxide (TMAO) and urinary makers of AKI: albumin, neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 and cystatin-C (uCyst-C) after long runs. Sixteen runners, mean age 36.7 ± 8.2 years, (2 women, 14 men) participating in 10- and 100-km races were studied. Blood and urine were taken before and after the races to assess markers of AKI. A statistically significant increase in creatinine, urea, uric acid, SDMA and all studied urinary AKI markers was observed. TMAO and ADMA levels did not change. The changes in studied markers seem to be a physiological reaction, because they were observed almost in every runner. The diagnosis of kidney failure after exercise is challenging. The most valuable novel markers which can help in post-exercise AKI diagnosis are uCyst-C and uNGAL.

Keywords: urinary biomarkers; uremic toxins; albuminuria; fractional excretion; SDMA; TMAO; ultramarathon (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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