Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?

Silvan Silva de Araújo, Felipe José Aidar, Dihogo Gama de Matos, Jymmys Lopes dos Santos, Lúcio Marques Vieira Souza, Albená Nunes da Silva, Rodrigo Miguel dos Santos, Anderson Carlos Marçal, Daniella Mota Mourão, Amário Lessa Júnior, Geraldo Magela Durães, André Luiz Gomes Carneiro, Rodrigo Gonçalves da Silva, Mauro Martins Teixeira and Charles dos Santos Estevam
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Silvan Silva de Araújo: Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
Felipe José Aidar: Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
Dihogo Gama de Matos: Group of Studies and Research of Performance, Sport, Health and Paralympic Sports—GEPEPS, Federal University of Sergipe, São Cristovão, Sergipe 49100-000, Brazil
Jymmys Lopes dos Santos: Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
Lúcio Marques Vieira Souza: Post-Graduate Program in Biotechnology, Northeast Network in Biotechnology (RENORBIO), Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
Albená Nunes da Silva: Exercise’s Inflammation and Immunology Laboratory, Sports Center, Federal University of Ouro Preto, Minas Gerais 35400-000, Brazil
Rodrigo Miguel dos Santos: Post-Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
Anderson Carlos Marçal: Post-Graduate Program in Physical Education, Federal University of Sergipe, São Cristóvão SE 49100-000, Brazil
Daniella Mota Mourão: Department of Medical Clinic, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil
Amário Lessa Júnior: Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil
Geraldo Magela Durães: Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil
André Luiz Gomes Carneiro: Department of Physical Education, State University of Montes Claros, Montes Claros, MG 39401-089, Brazil
Rodrigo Gonçalves da Silva: Department of Physical Education, University Funorte of Montes Claros, Montes Claros, MG 39401-089, Brazil
Mauro Martins Teixeira: Department of Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil
Charles dos Santos Estevam: Department of Physiology, Federal University of Sergipe, São Cristóvão, SE 49100-000, Brazil

IJERPH, 2019, vol. 16, issue 21, 1-11

Abstract: Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) ( p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) ( p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts.

Keywords: strength exercise; croton; oxidative stress; muscle damage; lipoperoxidation; hidroethanol extract (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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