Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses

Juliana de Melo Batista dos Santos, Roberta Foster, Anne-Charlotte Jonckheere, Marcelo Rossi, Luiz Antonio Luna Junior, Catherine Machado Katekaru, Matheus Cavalcante de Sá, Lucas Guimarães Pagani, Francine Maria de Almeida, Jônatas do Bussador Amaral, Rodolfo de Paula Vieira, Andre Luis Lacerda Bachi, Dominique Magdalena A Bullens and Mauro Vaisberg
Additional contact information
Juliana de Melo Batista dos Santos: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Roberta Foster: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Anne-Charlotte Jonckheere: Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, UZ Herestraat 49 box 811, 3000 Leuven, Belgium
Marcelo Rossi: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Luiz Antonio Luna Junior: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Catherine Machado Katekaru: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Matheus Cavalcante de Sá: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Lucas Guimarães Pagani: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Francine Maria de Almeida: Medicine School, São Paulo University, Av. Dr. Arnaldo, 455—Cerqueira César, São Paulo SP CEP 01246-903, Brazil
Jônatas do Bussador Amaral: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Rodolfo de Paula Vieira: Post-graduation Program in Science of Human and Rehabilitation, Federal University of São Paulo (UNIFESP), Av. Ana Costa, 95—Vila Mathias, Santos SP CEP 11060-001, Brazil
Andre Luis Lacerda Bachi: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil
Dominique Magdalena A Bullens: Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, UZ Herestraat 49 box 811, 3000 Leuven, Belgium
Mauro Vaisberg: ENT Lab, Department of Otorhinolaryngology, Federal University of São Paulo (UNIFESP), Rua dos Otonis, 700, Piso superior/Second floor, Sao Paulo SP CEP 04025-002, Brazil

IJERPH, 2019, vol. 16, issue 22, 1-18

Abstract: Although regular exercise-training improves immune/inflammatory status, the influence of air pollutants exposure during outdoor endurance training compared to a sedentary lifestyle has not yet been clarified. This study aimed to compare the immune/inflammatory responses in the airways of street runners and sedentary people after acute and chronic particulate matter (PM) exposure. Forty volunteers (street runners (RUN, n = 20); sedentary people (SED, n = 20)) were evaluated 1 (acute) and 10 (chronic) weeks after PM exposure. Cytokines [interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, IL-13, and IL-17A] in nasal lavage fluid, salivary antibacterial peptides (lactoferrin (LTF), cathelicidin (LL-37), defensin-α 1–3), and secretory immunoglobulin A (SIgA), plasma club cell protein (CC16), and fractional exhaled nitric oxide (FeNO) were analyzed. After acute exposure, the RUN group showed lower levels of IL-13, IL-10, and FeNO, but higher defensin-α than the SED group. After chronic exposure, the RUN group showed elevation of IFN-γ, IL-10, IL-17A, and a decrease of FeNO levels, whereas the SED group showed elevation of TNF-α, IL-6, IL-10, and a decrease of IL-13 levels. Comparing these groups, the RUN group showed higher levels of SIgA and LTF, and lower FeNO levels than the SED group. In relation to the Th immune response analysis after acute and chronic PM exposure, the RUN group showed a pattern associated with Th1, while in the SED group, a Th2 pattern was found. Both groups showed also a Th17 immune response pattern. Our results allow us to suggest that the immune/inflammatory status of the respiratory tract after acute and chronic PM exposure was improved by the long-standing regular practice of outdoor endurance exercise compared to a sedentary lifestyle.

Keywords: runners; air pollutants; cytokines; antibacterial peptides; fractional exhaled nitric oxide; Th immune response (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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