Alleviating Effect of ?-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats

Iwona Markiewicz-Górka, Krystyna Pawlas, Aleksandra Jaremków, Lidia Januszewska, Paweł Pawłowski and Natalia Pawlas
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Iwona Markiewicz-Górka: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland
Krystyna Pawlas: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland
Aleksandra Jaremków: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland
Lidia Januszewska: Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, Wroclaw, 50-345, Poland
Paweł Pawłowski: Specialist Hospital dr Alfred Sokołowski, Sokołowskiego 4, Wałbrzych 58-309, Poland
Natalia Pawlas: Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 38, Zabrze 41-808, Poland

IJERPH, 2019, vol. 16, issue 22, 1-25

Abstract: Cadmium exposure contributes to internal organ dysfunction and the development of chronic diseases. The aim of the study was to assess the alleviating effect of α-lipoic acid and/or magnesium on cadmium-induced oxidative stress and disorders in bone metabolism, kidney and liver function, and hematological and biochemical parameters changes. Male rats were exposed to cadmium (30 mg Cd/kg of feed) for three months. Some animals exposed to Cd were supplemented with magnesium (150 mg Mg/kg of feed) and/or with α-lipoic acid (100 mg/kg body weight, four times a week). Cd intake inhibited body weight gain and lowered hemoglobin concentration, whereas it increased the activities of liver enzymes, as well as the level of oxidative stress, CTX-1 (C-terminal telopeptide of type I collagen, bone resorption marker), and CRP (C-reactive protein, marker of inflammation); it decreased vitamin D3, GSH (reduced glutathione), and the serum urea nitrogen/creatinine index. Mg and/or α-lipoic acid supplementation increased the antioxidant potential, and partially normalized the studied biochemical parameters. The obtained results show that both magnesium and α-lipoic acid decrease oxidative stress and the level of inflammatory marker, as well as normalize bone metabolism and liver and kidney function. Combined intake of α-lipoic acid and magnesium results in reinforcement of the protective effect; especially, it increases antioxidant defense.

Keywords: cadmium; magnesium; ?-lipoic acid; oxidative stress; C-reactive protein; rats (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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