Clinical Outcomes of Penetrating Keratoplasty and Descemet Stripping Automated Endothelial Keratoplasty in Asian Population with American Corneas

Fang-Chi Hsiao, Po-Yuan Chen, Yaa-Jyuhn James Meir, Hsin-Yuan Tan, Ching-Hsi Hsiao, Hsin-Chiung Lin, David Hui-Kang Ma, Lung-Kun Yeh, Wei-Chi Wu and Hung-Chi Chen
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Fang-Chi Hsiao: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan
Po-Yuan Chen: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan
Yaa-Jyuhn James Meir: Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 33305, Taiwan
Hsin-Yuan Tan: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan
Ching-Hsi Hsiao: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan
Hsin-Chiung Lin: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan
David Hui-Kang Ma: Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 33305, Taiwan
Lung-Kun Yeh: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan
Wei-Chi Wu: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan
Hung-Chi Chen: Department of Medicine, College of Medicine Chang Gung University, Taoyuan 33302, Taiwan

IJERPH, 2019, vol. 16, issue 22, 1-12

Abstract: To determine the comparative efficacy and safety of penetrating keratoplasty ( PK) and Descemet stripping automated endothelial keratoplasty (DSAEK) in the Asian population receiving imported donor corneas, our single-center retrospective study provides analysis supporting the transition from PK to DSAEK in the Asian population using imported American donor corneas. We analyzed 259 patients with 241 and 57 cases of PK and DSAEK respectively during 2008 to 2017 using imported corneas at Chang Gung Memorial Hospital, Linkou, Taiwan. In terms of long-term graft survival analysis, there was no difference between PK and DSAEK (log-rank p = 0.386, HR = 0.920, 95% CI: [0.641–1.380]). However, Cox proportional regression analysis revealed that corneal survival rate of DSAEK group in the first 100 days after transplantation was inferior than that of PK group (log-rank p < 0.001, HR = 2.733, 95% CI: [1.501–4.977])]. Despite the inferior survival rate, there were significantly less neovascularization and Descemet membrane folds in the DSAEK group. Importantly, the non-complication rate of DSAEK was much higher than that of PK with significant difference (PK, 25.7% vs DSAEK 42.0%, p = 0.022). Collectively, DSAEK is suggested as an alternative surgical modality in Asian patients using imported American donor corneas because of less complication, and no difference in long-term corneal graft survival rates between PK and DSAEK.

Keywords: long term clinical outcomes; PK; DSAEK; imported corneas (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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