Lack of Association between Cytokine Genetic Polymorphisms in Takayasu’s Arteritis in Mexican Patients

María Elena Soto, Claudia Huesca-Gómez, Yazmín Torres-Paz, Giovanny Fuentevilla-Álvarez and Ricardo Gamboa
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María Elena Soto: Immunology Department, Instituto Nacional de Cardiología “Ignacio Chávez”. Juan Badiano No. 1, Col. Sección XVI, Tlalpan, México City 14080, Mexico
Claudia Huesca-Gómez: Physiology Department, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico
Yazmín Torres-Paz: Physiology Department, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico
Giovanny Fuentevilla-Álvarez: Physiology Department, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico
Ricardo Gamboa: Physiology Department, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico

IJERPH, 2019, vol. 16, issue 23, 1-11

Abstract: Aim : To investigate the relation between polymorphisms in the interleukin 10 ( IL )- 10 , tumor necrosis factor ( TNF) -α, transforming growth factor ( TGF)- β and interferon ( IFN)-γ genes and Takayasu’s arteritis in the Mexican population. Methods : A case-control study was performed to investigate the associations of IL-10 , TNF-α , TGF-β and IFN-γ polymorphisms in a sample of 52 Takayasu’s arteritis patients, diagnosed according to the criteria of the American College of Rheumatology and EULAR PRINTO criteria when the patients were under 18 years of age; 60 clinically healthy unrelated Mexican individuals by the 5′ exonuclease TaqMan polymerase chain reaction. Polymorphic haplotypes were constructed after linkage disequilibrium analysis. Results: Significant differences were not found in the distribution for genotype and allele frequencies of the polymorphisms studied between healthy controls and Takayasu´s arteritis patients. Likewise, significant associations were not detected in the haplotype analysis with the different genes studied. Conclusions : These findings suggest that the polymorphisms in IL-10 , TNF-α , TGF-β and IFN-γ might not contribute to the susceptibility of Takayasu´s arteritis in the Mexican population.

Keywords: cytokines; Takayasu?s arteritis; polymorphisms; Mexican population (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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