Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis

Elvin T. Ng, Russell Z. Ang, Bach X. Tran, Cyrus S. Ho, Zhisong Zhang, Wanqiu Tan, Yu Bai, Min Zhang, Wilson W. Tam and Roger C. Ho
Additional contact information
Elvin T. Ng: Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China
Russell Z. Ang: Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
Bach X. Tran: Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam
Cyrus S. Ho: Department of Psychological Medicine, National University Hospital, Singapore 119228, Singapore
Zhisong Zhang: Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China
Wanqiu Tan: Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore
Yu Bai: Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China
Min Zhang: Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China
Wilson W. Tam: Alice Lee School of Nursing, National University of Singapore, Singapore 117597, Singapore
Roger C. Ho: Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China

IJERPH, 2019, vol. 16, issue 24, 1-10

Abstract: The purpose of our study was to carry out a meta-analysis of current literature to determine whether total mastectomy and breast-conserving surgery induce different outcomes in quality of life, based on the breast-cancer-specific module of the European Organizaation for Research and Treatment of Cancer core questionnaire (EORTC QLQ-BR23) used postoperatively. A systematic literature search of PubMed and EMBASE was conducted. Observational clinical studies that compared the quality of life in different surgery groups and presented empirical findings were selected. Six studies met the inclusion criteria. Breast-conserving surgery has statistically significant better outcomes than mastectomy in three of the eight outcomes measured in the EORTC QLQ-BR23, namely body image (standard mean difference, SMD = 1.742, 95% CI 0.579–2.905, p = 0.003), future perspective (SMD = 0.606, 95% CI 0.075–1.138, p = 0.025) and systemic therapy side effects (SMD = −0.641, 95% CI 0.101–1.181, p = 0.020). Our study highlighted that breast-conserving surgery was preferred over mastectomy because breast-conserving surgery leads to better outcomes in body image, future perspectives and less systemic side effects.

Keywords: breast cancer; breast conserving; individualised patient profiles; patient stratification; phenotyping; quality of life; mastectomy; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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