The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study

Hung-Jui Hsu, Chia-Yi Lee, Shih-Chun Chao, Chan-Wei Nien, Shih-Hao Tzeng, Jing-Yang Huang, Tai-Chuan Ko, Shun-Fa Yang and Hung-Yu Lin
Additional contact information
Hung-Jui Hsu: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Chia-Yi Lee: Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
Shih-Chun Chao: Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
Chan-Wei Nien: Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
Shih-Hao Tzeng: Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
Jing-Yang Huang: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Tai-Chuan Ko: Department of Optometry, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Hung-Yu Lin: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan

IJERPH, 2019, vol. 16, issue 24, 1-10

Abstract: The aim of the present study was to survey the relationship between central serous chorioretinopathy (CSC) and several cardiovascular diseases (CVDs) with different severities using the National Health Insurance Research Database. A retrospective cohort study was conducted. Subjects with CSC were enrolled according to the relevant diagnostic codes, and an age- and gender-matched population was used as the control group with a 1:4 ratio. The main outcome being considered was the development of CVD after CSC exposure. Cox proportional hazard regression was applied to calculate the adjusted hazard ratio (aHR) of CSC and CVD of different types. A total of 2865 patients that were diagnosed with CSC were enrolled in the study group, while another 11,460 non-CSC subjects were selected as the control group. There were 171 events of CVD which occurred in the study group, while another 557 cases were found in the control group. No significant differences were observed among the CVD cases between the study and control group, whether they had an acute or chronic form, according to the aHR. In the subgroup analysis, there was a significantly higher risk of CVD development in the male population aged from 40 to 59 years (aHR: 1.351, confidence interval (CI): 1.063–1.716), which was mainly due to the higher risk of mild CVD (aHR: 1.391, CI: 1.062–1.822). On the contrary, there was no significant difference in CVD development in any of the age subgroups of the female population. In conclusion, the existence of CSC is correlated with a higher rate of chronic CVD occurrence in the middle-aged male population.

Keywords: central serous chorioretinopathy; cardiovascular disease; atherosclerosis; severity; epidemiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/16/24/5099/pdf (application/pdf)
https://www.mdpi.com/1660-4601/16/24/5099/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:16:y:2019:i:24:p:5099-:d:297789

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().