Medication Event Monitoring System for Infectious Tuberculosis Treatment in Morocco: A Retrospective Cohort Study

Seup Park, Ilham Sentissi, Seung Jae Gil, Won-Seok Park, ByungKwon Oh, Ah Reum Son, Young Ju Kong, Sol Park, Eunseong Paek, Yong Joon Park and Seung Heon Lee
Additional contact information
Seup Park: Global Care International, Seoul 08377, Korea
Ilham Sentissi: Chief Public Health Service and Epidemiological Surveillance, Moroccan League Against Tuberculosis (Ligue Marocaine de Lute Contre la Tuberculosis, LMCT), Rabat 10000, Morocco
Seung Jae Gil: Global Care International, Seoul 08377, Korea
Won-Seok Park: Global Care International, Seoul 08377, Korea
ByungKwon Oh: Global Care International, Seoul 08377, Korea
Ah Reum Son: Global Care International, Seoul 08377, Korea
Young Ju Kong: Global Care International, Seoul 08377, Korea
Sol Park: Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan-City 15355, Korea
Eunseong Paek: Global Care International, Seoul 08377, Korea
Yong Joon Park: Global Care International, Seoul 08377, Korea
Seung Heon Lee: Global Care International, Seoul 08377, Korea

IJERPH, 2019, vol. 16, issue 3, 1-9

Abstract: Non-adherence to tuberculosis (TB) treatment is a barrier to effective TB control. We investigated the effectiveness of a Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention in Morocco. We compared patients who received a MEMS (n = 206) with patients who received standard TB care (n = 141) among new active TB patients with sputum smear-positive. The mean total medication days were 141.87 ± 29.5 in the control group and 140.85 ± 17.9 in the MEMS group ( p = 0.7147), and the mean age and sex were not different between the two groups ( p > 0.05). The treatment success rate was significantly higher in the MEMS group than in the control group (odds ratio (OR): 4.33, 95% confidence interval (CI): 2.13–8.81, p < 0.001), and the lost to follow-up rate was significantly lower in the MEMS group than in the control group (OR: 0.03, 95% CI: 0.05–0.24, p < 0.001) after adjusting for sex, age, and health centers. The mean drug adherence rate in the first month was significantly higher in the MEMS group than in the control group ( p = 0.023). MEMS increased TB treatment success rate and decreased the lost to follow-up rate overall for infectious TB patients in a Moroccan rural area.

Keywords: tuberculosis; medication event monitoring system; success rate; lost to follow-up rate; Morocco (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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