The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day

Hongyan Zhu, Rui Li, Su Zhou, Suhui Zhang, Yu Wang, Shihong Liu, Qingwen Song, Xiuli Chang, Yubin Zhang, Luqing Liu, Liming Tang and Zhijun Zhou
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Hongyan Zhu: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Rui Li: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Su Zhou: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Suhui Zhang: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Yu Wang: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Shihong Liu: School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China
Qingwen Song: School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China
Xiuli Chang: School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China
Yubin Zhang: School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China
Luqing Liu: School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China
Liming Tang: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Zhijun Zhou: School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China

IJERPH, 2019, vol. 16, issue 4, 1-7

Abstract: A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide.

Keywords: Flurochloridone; subchronic toxicity; NOAEL; male reproductive system (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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