Association of Circulating Irisin Concentrations with Weight Loss after Roux-en-Y Gastric Bypass Surgery

Yeon Ji Lee, Yoonseok Heo, Ji-Ho Choi, Sunghyouk Park, Kyoung Kon Kim, Dong Wun Shin and Ju-Hee Kang
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Yeon Ji Lee: Department of Family Medicine, Obesity Center, Inha University Hospital, Inha University, Incheon 22332, Korea
Yoonseok Heo: Department of Surgery, Inha University Hospital, Inha University, Incheon 22332, Korea
Ji-Ho Choi: Department of Family Medicine, Obesity Center, Inha University Hospital, Inha University, Incheon 22332, Korea
Sunghyouk Park: College of Pharmacy, Natural Product Research Institute, Seoul National University, Seoul 08826, Korea
Kyoung Kon Kim: Department of Family Medicine, Gil Hospital, Gachon School of Medicine, Incheon 21565, Korea
Dong Wun Shin: Department of Emergency Medicine, Inje University Ilsan Paik Hospital, Gyeonggi-Do 10380, Korea
Ju-Hee Kang: Department of Pharmacology and Hypoxia-related Disease Research Center, College of Medicine, Inha University, Incheon 22212, Korea

IJERPH, 2019, vol. 16, issue 4, 1-10

Abstract: Irisin is a myokine with potential anti-obesity properties that has been suggested to increase energy expenditure in obese patients. However, there is limited clinical information on the biology of irisin in humans, especially in morbidly obese patients undergoing bariatric surgery. We aimed to assess the association of circulating irisin concentrations with weight loss in obese patients undergoing bariatric surgery. This was a pilot, single-centre, longitudinal observational study. We recruited 25 morbidly obese subjects who underwent Roux-en-Y gastric bypass surgery (RYGBP), and blood samples from 12 patients were taken to measure serum irisin concentrations before, and one and nine months after surgery. Their clinical characteristics were measured for one year. The preoperative serum irisin concentration (mean 1.01 ± 0.23 μg/mL, range 0.73–1.49) changed bidirectionally one month after RYGBP. The mean concentration at nine months was 1.11 ± 0.15 μg/mL (range 0.92–1.35). Eight patients had elevated irisin levels compared with their preoperative values, but four did not. Elevations of irisin levels nine months, but not one month, after surgery, were associated with lower preoperative levels ( p = 0.016) and worse weight reduction rates ( p = 0.006 for the percentage excess weight loss and p = 0.032 for changes in body mass index). The preoperative serum irisin concentrations were significantly correlated with the percentage of excess weight loss for one year (R 2 = 0.612; p = 0.04) in our study. Our results suggest that preoperative circulating irisin concentrations may be at least in part associated with a weight loss effect of bariatric surgery in morbidly obese patients. Further large-scale clinical studies are needed to ratify these findings.

Keywords: bariatric surgery; irisin; myokine; obesity; Roux-en-Y gastric bypass; weight loss (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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