Alterations by Air Pollution in Inflammation and Metals in Pleural Effusion of Pneumonia Patients

Kuan-Jen Bai, Kai-Jen Chuang, Jen-Kun Chen, Cheng-Yu Tsai, You-Lan Yang, Chih-Cheng Chang, Tzu-Tao Chen, Chun-Nin Lee, Po-Hao Feng, Kuan-Yuan Chen, Kang-Yun Lee, Chein-Ling Su, Shu-Chuan Ho, Sheng-Ming Wu and Hsiao-Chi Chuang
Additional contact information
Kuan-Jen Bai: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Kai-Jen Chuang: School of Public Health, College of Public Health, Taipei Medical University, Taipei 110, Taiwan
Jen-Kun Chen: Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan
Cheng-Yu Tsai: Sleep Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan
You-Lan Yang: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Chih-Cheng Chang: Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Tzu-Tao Chen: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan
Chun-Nin Lee: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Po-Hao Feng: Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Kuan-Yuan Chen: Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan
Kang-Yun Lee: Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Chein-Ling Su: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Shu-Chuan Ho: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Sheng-Ming Wu: Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Hsiao-Chi Chuang: School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, Taiwan

IJERPH, 2019, vol. 16, issue 5, 1-10

Abstract: Air pollution is known to increase the risk of pneumonia. However, the effects of air pollution on the pleural effusion of patients with pneumonia are unclear. The objective of this study was to investigate alterations in inflammatory–immune biomarkers by air pollution in patients with pneumonia by analyzing their pleural effusion. Patients who had undergone thoracentesis to drain their pleural effusion in a hospital were recruited for this study. Patients with pneumonia and those with congestive heart failure respectively served as the case and control groups. We observed that an increase of 1 ppb in one-year NO 2 was associated with a decrease of 0.105 ng/mL in cluster of differentiation 62 (CD62) (95% confidence interval (CI) = −0.085, −0.004, p < 0.05) in the pleural effusion. Furthermore, we observed that an increase in one−year 1 ppb of NO 2 was associated with a decrease of 0.026 ng/mL in molybdenum (Mo) (95% CI = −0.138, −0.020, p < 0.05). An increase in one-year 1 ppb of SO 2 was associated with a decrease of 0.531 ng/mL in zinc (95% CI = −0.164, −0.006, p < 0.05). Also, an increase in one-year 1 ppb of O 3 was associated with a decrease of 0.025 ng/mL in Mo (95% CI = −0.372, −0.053, p < 0.05). In conclusion, air pollution exposure, especially gaseous pollution, may be associated with the regulation of immune responses and changes in metal levels in the pleural effusion of pneumonia patients.

Keywords: air pollution; heart failure; immune function; infection; metal (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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