Short-Term Consumption of Cuban Policosanol Lowers Aortic and Peripheral Blood Pressure and Ameliorates Serum Lipid Parameters in Healthy Korean Participants: Randomized, Double-Blinded, and Placebo-Controlled Study

Hye-Jeong Park, Dhananjay Yadav, Da-Jeong Jeong, Suk-Jeong Kim, Myung-Ae Bae, Jae-Ryong Kim and Kyung-Hyun Cho
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Hye-Jeong Park: Research Institute of Protein Sensor, Yeungnam University, Gyeongsan 712-749, Korea
Dhananjay Yadav: Department of Medical Biotechnology, Yeungnam University, Gyeongsan 712-749, Korea
Da-Jeong Jeong: Research Institute of Protein Sensor, Yeungnam University, Gyeongsan 712-749, Korea
Suk-Jeong Kim: Research Institute of Protein Sensor, Yeungnam University, Gyeongsan 712-749, Korea
Myung-Ae Bae: Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Taejon 305-343, Korea
Jae-Ryong Kim: Department of Biochemistry and Molecular Biology, Smart-Aging Convergence Research Center, College of Medicine, Yeungnam University, Daegu 705-717, Korea
Kyung-Hyun Cho: Research Institute of Protein Sensor, Yeungnam University, Gyeongsan 712-749, Korea

IJERPH, 2019, vol. 16, issue 5, 1-15

Abstract: The current study was designed to investigate the short-term effects of policosanol consumption on blood pressure (BP) and the lipid parameters in healthy Korean participants with prehypertension. A total of 84 healthy participants were randomly allocated to three groups receiving placebo, 10 mg of policosanol, or 20 mg of policosanol for 12 weeks. Based on an average of three measurements of peripheral BP, the policosanol 20 mg group exhibited the most significant reduction, that is, up to 7.7% reduction of average systolic BP (SBP) from 136.3 ± 6.1 mmHg (week 0) to 125.9 ± 8.6 mmHg (week 12, p < 0.001). Between group comparisons using repeated measures ANOVA showed that the policosanol 20 mg group had a significant reduction of SBP at 12 weeks ( p = 0.020) and a reduction of diastolic BP (DBP) at 8 weeks ( p = 0.041) and 12 weeks ( p = 0.035). The policosanol 10 mg and 20 mg groups showed significant reductions in aortic SBP of 7.4% and 8.3%, respectively. The policosanol groups showed significant reductions of total cholesterol (TC) of 9.6% and 8.6% and low-density lipoproteins (LDL-C) of 21% and 18% for 10 mg and 20 mg of policosanol, respectively. Between group comparisons using repeated measures ANOVA showed that the policosanol (10 mg and 20 mg) groups at 12 weeks had a significant reduction of TC ( p = 0.0004 and p = 0.001) and LDL-C ( p = 0.00005 and p = 0.0001) and elevation of %HDL-C ( p = 0.048 and p = 0.014). In conclusion, 12-week consumption of policosanol resulted in significant reductions of peripheral SBP and DBP, aortic SBP and DBP, mean arterial pressure (MAP), and serum TC and LDL-C with elevation of % HDL-C.

Keywords: policosanol; blood pressure; high-density lipoproteins; low-density lipoproteins (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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