Anti-Müllerian Hormone Gene Polymorphism is Associated with Clinical Pregnancy of Fresh IVF Cycles

Cheng-Hsuan Wu, Shun-Fa Yang, Hui-Mei Tsao, Yu-Jun Chang, Tsung-Hsien Lee and Maw-Sheng Lee
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Cheng-Hsuan Wu: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Hui-Mei Tsao: Division of Infertility Clinic, Lee Womens’ Hospital, Taichung 406, Taiwan
Yu-Jun Chang: Epidemiology and Biostatistics Center, Changhua Christian Hospital, Changhua 50006, Taiwan
Tsung-Hsien Lee: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Maw-Sheng Lee: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

IJERPH, 2019, vol. 16, issue 5, 1-11

Abstract: The aim of this study was to examine the effects of single-nucleotide polymorphisms (SNPs) in the anti-Müllerian hormone (AMH) and AMH type II receptor (AMHRII) genes on in vitro fertilization (IVF) outcomes. In this prospective cohort study, we genotyped the AMH 146 T > G, AMHRII −482 A > G and AMHRII IVS1 +149 T > A variants in 635 women undergoing their first cycle of controlled ovarian stimulation for IVF. DNA was extracted from the peripheral blood of all participants, and the SNPs were genotyped by real-time polymerase chain reaction. The distributions, frequencies of genes, and correlation with clinical pregnancy of IVF were analyzed. The AMH 146 T > G G/G genotype in women was associated with a lower clinical pregnancy rate (T/T: 55.0%, T/G: 51.8%, G/G: 40.0%; p < 0.05). Women with the AMH 146 T > G GG genotype were half as likely to have a clinical pregnancy compared with women with TT genotypes (OR = 0.55, 95% CI: 0.34–0.88, p = 0.014). With multivariate analysis, the AMH 146 T > G GG genotype remains as a significant independent factor to predict clinical pregnancy ( p = 0.014). No significant difference was found between AMHRII polymorphisms and clinical pregnancy outcomes of IVF. In conclusion, our results show that AMH 146 T > G seems to be a susceptibility biomarker capable of predicting IVF pregnancy outcomes. Further studies should focus on the mechanism of these associations and the inclusion of other ethnic populations to confirm the findings of this study.

Keywords: Anti-Müllerian hormone; Anti-Müllerian hormone type II receptor; AMH polymorphism; AMHRII polymorphism; IVF outcomes (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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