The Relationship between Eicosanoid Levels and Serum Levels of Metabolic and Hormonal Parameters Depending on the Presence of Metabolic Syndrome in Patients with Benign Prostatic Hyperplasia

Katarzyna Grzesiak, Aleksandra Rył, Ewa Stachowska, Marcin Słojewski, Iwona Rotter, Weronika Ratajczak, Olimpia Sipak, Małgorzata Piasecka, Barbara Dołęgowska and Maria Laszczyńska
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Katarzyna Grzesiak: Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, Szczecin 71-210, Poland
Aleksandra Rył: Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin 71-210, Poland
Ewa Stachowska: Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, Szczecin 71-460, Poland
Marcin Słojewski: Department of Urology and Urological Oncology, Pomeranian Medical University, Powstańców Wlkp. 72, Szczecin 70-111, Poland
Iwona Rotter: Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin 71-210, Poland
Weronika Ratajczak: Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, Szczecin 71-210, Poland
Olimpia Sipak: Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University, Żołnierska 48, Szczecin 71-210, Poland
Małgorzata Piasecka: Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, Szczecin 71-210, Poland
Barbara Dołęgowska: Department of Microbiology, Immunology, and Laboratory Medicine, Pomeranian Medical University, Powstańców Wlkp. 72, Szczecin 70-111, Poland
Maria Laszczyńska: Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, Szczecin 71-210, Poland

IJERPH, 2019, vol. 16, issue 6, 1-11

Abstract: Background : The purpose of our investigation was to analyze the relationship between the serum levels of inflammatory mediators (HETE, HODE) and the levels of selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). Methods : The study involved 151 men with BPH. Blood samples were taken for laboratory analysis of the serum levels of metabolic and hormonal parameters. Gas chromatography was performed using an Agilent Technologies 7890A GC System. Results : We found that waist circumference was the only parameter related to the levels of fatty acids, namely: 13(S)-HODE, 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE. In the patients with BPH and MetS, triglycerides correlated with 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE, which was not observed in the patients without MetS. Similarly, total cholesterol correlated with 9(S)-HODE, and 15(S)-HETE in the patients with BPH and MetS, but not in those without MetS. In the group of BPH patients with MetS, total testosterone positively correlated with 13(S)-HODE, and free testosterone with 9(S)-HODE. Conclusions : Based on this study, it can be concluded that lipid mediators of inflammation can influence the levels of biochemical and hormonal parameters, depending on the presence of MetS in BPH patients.

Keywords: metabolic syndrome; benign prostatic hyperplasia; fatty acids (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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