Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

Cheng-Hsuan Wu, Tsung-Hsien Lee, Shun-Fa Yang, Hui-Mei Tsao, Yu-Jun Chang, Chia-Hsuan Chou and Maw-Sheng Lee
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Cheng-Hsuan Wu: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Tsung-Hsien Lee: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Hui-Mei Tsao: Division of Infertility Clinic, Lee Womens’ Hospital, Taichung 406, Taiwan
Yu-Jun Chang: Epidemiology and Biostatistics Center, Changhua Christian Hospital, Changhua 50006, Taiwan
Chia-Hsuan Chou: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Maw-Sheng Lee: Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

IJERPH, 2019, vol. 16, issue 6, 1-11

Abstract: The aim of this study was to examine the association between interleukin (IL) genes polymorphisms and in vitro fertilization (IVF) outcome. A prospective cohort analysis was performed at a Women’s Hospital IVF centre of 1015 female patients undergoing fresh non-donor IVF cycles. The effects of the following six single nucleotide polymorphisms (SNPs) in five IL genes on IVF outcomes were explored: IL-1α (rs1800587 C/T), IL-3 (rs40401 C/T), IL-6 (rs1800795 C/G), IL-15 (rs3806798 A/T), IL-18 (rs187238 C/G) and IL-18 (rs1946518 G/T). The main outcome measures included clinical pregnancy, embryo implantation, abortion and live birth rates. There were no statistically significant differences in clinical pregnancy, embryo implantation and live birth rates in the analysis of 1015 patients attempting their first cycle of IVF. Infertile women with IL-3 homozygous major genotype had a higher abortion rate than those with heterozygous and homozygous minor genotype (16.5% vs. 7.9%, P = 0.025). In conclusion, our results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients. Future studies with inclusion of other ethnic populations must be conducted to confirm the findings of this study.

Keywords: abortion; IVF outcomes; interleukin; polymorphism (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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