Research Trends and Hotspots Analysis Related to Monocarboxylate Transporter 1: A Study Based on Bibliometric Analysis

Siyi He, Yue Zhao, Yongsheng Fan, Xue Zhao, Jun Yu, Jie Xie, Chunhong Wang and Jianmei Su
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Siyi He: Department of Preventive Medicine, School of Public Health, Wuhan University, Wuhan 430071, China
Yue Zhao: Department of Preventive Medicine, School of Public Health, Wuhan University, Wuhan 430071, China
Yongsheng Fan: Department of Toxicology, School of Public Health, Wuhan University, Wuhan 430071, China
Xue Zhao: Department of Toxicology, School of Public Health, Wuhan University, Wuhan 430071, China
Jun Yu: Department of Toxicology, School of Public Health, Wuhan University, Wuhan 430071, China
Jie Xie: Department of Toxicology, School of Public Health, Wuhan University, Wuhan 430071, China
Chunhong Wang: Department of Toxicology, School of Public Health, Wuhan University, Wuhan 430071, China
Jianmei Su: Department of Toxicology, School of Public Health, Wuhan University, Wuhan 430071, China

IJERPH, 2019, vol. 16, issue 7, 1-15

Abstract: Background : Monocarboxylate transport protein 1 (MCT1) has been defined as a critical regulator in tumor energy metabolism, but bibliometric analysis of MCT1 research is rare. This study aimed to comprehensively analyze the global scientific output of MCT1 research and explore the hotspots and frontiers from the past decade. Methods : Publications and their literature information from 2008 to 2018 were retrieved from the Web of Science Core Collection database. We used Microsoft Excel 2016 to detect the trend of annual numbers of publications, and used Citespace V software as the bibliometric method to analyze the research areas, countries, institutions, authors, journals, research hotspots, and research frontiers. Results : A total of 851 publications were identified with an increasing trend. Relevant literature mainly focused on the field of oncology. The most prolific country and institution were the USA and University of Minho, respectively. Baltazar was the most productive author while Halestrap had the highest co-citations. The hottest topics in MCT1 were hypoxia, gene expression, and CD147 over the last decade. The three research frontier topics were proliferation, tumor cell, and resistance. The special role of MCT1 in human tumor cells has become the focus for scholars recently. Conclusion : The development prospects of MCT1 research could be expected and researchers should pay attention to the clinical significance of MCT1 inhibitors as anti-cancer or immunosuppressive drugs and the possibility of drug-resistance formation.

Keywords: monocarboxylate transport protein 1; neoplasms; CiteSpace; bibliometrics (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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