Impaired Glucose Metabolism in Bipolar Patients: The Role of Psychiatrists in Its Detection and Management

Dorota Łojko, Maciej Owecki and Aleksandra Suwalska
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Dorota Łojko: Department of Adult Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland
Maciej Owecki: Department of Public Health, Chair of Social Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland
Aleksandra Suwalska: Department of Mental Health, Chair of Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, Poland

IJERPH, 2019, vol. 16, issue 7, 1-12

Abstract: Bipolar patients have a higher risk of type 2 diabetes and obesity, which are associated with cardiovascular diseases as the leading cause of death in this group. Additionally, there is growing evidence that impaired glucose metabolism in bipolar patients is associated with rapid cycling, poor response to mood stabilizers and chronic course of illness. The aim of the study was to assess the prevalence of type 2 diabetes and other types of impaired glucose metabolism in bipolar patients along with an evaluation of the Fasting Triglycerides and Glucose Index (TyG) as a method of the insulin sensitivity assessment. The analysis of fasting glycemia, insulinemia and lipid profile in euthymic bipolar patients was performed, and the Homeostasis model assessment for insulin resistance (HOMA-IR) and TyG were computed. Type 2 diabetes was observed in 9% and insulin resistance with HOMA-IR in 48% of patients. The TyG and HOMA-IR indices were correlated ( p < 0.0001), the TyG index value of 4.7 had the highest sensitivity and specificity for insulin resistance detection. The usefulness of TyG in the recognition of insulin resistance in bipolar patients was suggested. The significant role of psychiatrists in the detection and management of impaired glucose metabolism in bipolar patients was presented.

Keywords: bipolar disorder; insulin resistance; type 2 diabetes; TyG; HOMA; impaired glucose metabolism; comorbidity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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