Exposure to Atmospheric Ultrafine Particles Induces Severe Lung Inflammatory Response and Tissue Remodeling in Mice

Yara Saleh, Sébastien Antherieu, Romain Dusautoir, Laurent Y. Alleman, Jules Sotty, Corentin De Sousa, Anne Platel, Esperanza Perdrix, Véronique Riffault, Isabelle Fronval, Fabrice Nesslany, Ludivine Canivet, Guillaume Garçon and Jean-Marc Lo-Guidice
Additional contact information
Yara Saleh: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Sébastien Antherieu: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Romain Dusautoir: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Laurent Y. Alleman: Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France
Jules Sotty: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Corentin De Sousa: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Anne Platel: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Esperanza Perdrix: Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France
Véronique Riffault: Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France
Isabelle Fronval: Département Sciences de l’Atmosphère et Génie de l’Environnement (SAGE), IMT Lille Douai, Université de Lille, 59000 Lille, France
Fabrice Nesslany: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Ludivine Canivet: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Guillaume Garçon: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France
Jean-Marc Lo-Guidice: EA4483-IMPECS, Institut Pasteur de Lille, Université de Lille, CHU Lille, 59045 Lille CEDEX, France

IJERPH, 2019, vol. 16, issue 7, 1-18

Abstract: Exposure to particulate matter (PM) is leading to various respiratory health outcomes. Compared to coarse and fine particles, less is known about the effects of chronic exposure to ultrafine particles, despite their higher number and reactivity. In the present study, we performed a time-course experiment in mice to better analyze the lung impact of atmospheric ultrafine particles, with regard to the effects induced by fine particles collected on the same site. Trace element and PAH analysis demonstrated the almost similar chemical composition of both particle fractions. Mice were exposed intranasally to FF or UFP according to acute (10, 50 or 100 µg of PM) and repeated (10 µg of PM 3 times a week during 1 or 3 months) exposure protocols. More particle-laden macrophages and even greater chronic inflammation were observed in the UFP-exposed mice lungs. Histological analyses revealed that about 50% of lung tissues were damaged in mice exposed to UFP for three months versus only 35% in FF-exposed mice. These injuries were characterized by alveolar wall thickening, macrophage infiltrations, and cystic lesions. Taken together, these results strongly motivate the update of current regulations regarding ambient PM concentrations to include UFP and limit their emission.

Keywords: Ultrafine particles; mice; (sub)chronic exposure; inflammation; lung tissue remodeling (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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