Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature

Salvatore Savasta, Alessandra Rossi, Thomas Foiadelli, Amelia Licari, Anna Maria Elena Perini, Giovanni Farello, Alberto Verrotti and Gian Luigi Marseglia
Additional contact information
Salvatore Savasta: Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy
Alessandra Rossi: Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy
Thomas Foiadelli: Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy
Amelia Licari: Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy
Anna Maria Elena Perini: Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy
Giovanni Farello: Pediatric Clinic–Department of Life, Health and Environmental Sciences–Piazzale Salvatore Tommasi 1, 67100 Coppito (AQ), Italy
Alberto Verrotti: Pediatric Clinic–Biotechnological and Applied Clinical Sciences Via Vetoio (Coppito 2), 67100 Coppito (AQ), Italy
Gian Luigi Marseglia: Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy

IJERPH, 2019, vol. 16, issue 7, 1-13

Abstract: Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses.

Keywords: Melkersson Rosenthal Syndrome; fissured tongue; peripheral facial palsy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/16/7/1289/pdf (application/pdf)
https://www.mdpi.com/1660-4601/16/7/1289/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:16:y:2019:i:7:p:1289-:d:221640

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().