Different Associations between DC-SIGN Promoter-336G/A ( rs4804803 ) Polymorphism with Severe Dengue in Asians and South-Central Americans: a Meta-Analysis

Jiangping Ren, Zhengting Wang and Enfu Chen
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Jiangping Ren: Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou 310051, China
Zhengting Wang: Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou 310051, China
Enfu Chen: Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou 310051, China

IJERPH, 2019, vol. 16, issue 8, 1-13

Abstract: Objective : This study was conducted to identify the association between rs4804803 polymorphism in DC-SIGN with the susceptibility of severe dengue. Methods : A comprehensive search was conducted to identify all eligible papers in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Google Scholar. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were used to assess the association. Subgroup analyses were performed by ethnicity. Sensitivity analyses were performed through employing different statistical models (fixed versus random effect model). Results : A total of nine papers and 12 studies, with 1520 severe dengue and 1496 clinical dengue infection were included. The overall meta-analysis revealed significant associations between rs4804803 and severe dengue under the recession ( GG versus GA/AA : OR = 0.44, 95%CI, 0.23–0.82) and a codominant model ( GG versus AA : OR = 0.43, 95%CI, 0.23–0.81), but sensitivity analysis indicated that the significant pooled ORs were not robust. The subgroup analysis suggested that the carrier of G in rs4804803 was a risk factor for severe dengue under dominant ( GG/GA versus AA : OR = 1.86,95%CI, 1.01–3.45), superdominant ( GA versus GG/AA : OR = 1.81,95%CI, 1.02–3.21) and a codominant ( GA versus AA : OR=1.82,95%CI, 1.02–3.26) models in Asians, while it was a protective factor for severe dengue in South-central Americans under recessive ( GG versus GA/AA : OR = 0.27,95%CI, 0.10–0.70) and codominant ( GG versus AA : OR=0.24,95%CI, 0.09–0.64) models. The results from subgroup analysis were robust. Conclusions : Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin ( DC-SIGN ) promoter-336G/A ( rs4804803 ) polymorphism is association with severe dengue, and it acts in different directions for Asians and South-central Americans.

Keywords: dengue; polymorphism; DC-SIGN; rs4804803; Meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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