The Relationship between the HLA-G Polymorphism and sHLA-G Levels in Parental Pairs with High-Risk Pregnancy

Olimpia Sipak, Aleksandra Rył, Anna Grzywacz, Maria Laszczyńska, Małgorzata Zimny, Beata Karakiewicz, Iwona Rotter, Danuta Kosik-Bogacka and Cezary Cybulski
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Olimpia Sipak: Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Aleksandra Rył: Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Anna Grzywacz: Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 70-103 Szczecin, Poland
Maria Laszczyńska: Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Małgorzata Zimny: Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Beata Karakiewicz: Department of Public Health, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Iwona Rotter: Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
Danuta Kosik-Bogacka: Independent of Pharmaceutical Botany, Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
Cezary Cybulski: Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland

IJERPH, 2019, vol. 16, issue 9, 1-9

Abstract: Human leukocyte antigen G (HLA-G) is observed in immune system cells and other organs. It is a class Ib molecule, which plays a pivotal role in the implantation and maintenance of pregnancy. The aim of this study was to assess the relationship between serum sHLA-G levels and the HLA-G allele in parental pairs with complicated obstetric histories. The clinical material consisted of 210 women and 190 men with the experience of a complicated or an unsuccessful pregnancy. The control group included parents?89 women and 86 men?lacking complicated obstetric histories. We applied genetic analysis methods: isolation of genomic DNA, sequencing, and determination of serum sHLA-G levels. There were no statistically significant differences in the frequencies of the HLA-G −725 C>G polymorphism between particular experimental groups compared with the control group ( p > 0.05). The median sHLA-G levels in the women with the HLA-G10101 allele (15.4 U/mL) were significantly higher than in the women with other alleles ( p < 0.05). The HLA-G 10101 allele seems to protect against antiphospholipid syndrome, which may be associated with increased serum sHLA-G levels in its carriers. The relationship between serum sHLA-G levels and the HLA-G polymorphisms in the Polish population requires further investigation.

Keywords: HLA-G; allele; complicated pregnancy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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