The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease

Alessandro Federico, Marcello Dallio, Antonietta Gerarda Gravina, Nadia Diano, Sonia Errico, Mario Masarone, Mario Romeo, Concetta Tuccillo, Paola Stiuso, Filomena Morisco, Marcello Persico and Carmelina Loguercio
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Alessandro Federico: Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy
Marcello Dallio: Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy
Antonietta Gerarda Gravina: Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy
Nadia Diano: Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via De Crecchio 7, 80138 Naples, Italy
Sonia Errico: Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Via De Crecchio 7, 80138 Naples, Italy
Mario Masarone: Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, Via Allende, Baronissi, 84081 Salerno, Italy
Mario Romeo: Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy
Concetta Tuccillo: Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy
Paola Stiuso: Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy
Filomena Morisco: Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy
Marcello Persico: Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, Via Allende, Baronissi, 84081 Salerno, Italy
Carmelina Loguercio: Department of Precision Medicine, University of Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy

IJERPH, 2020, vol. 17, issue 10, 1-16

Abstract: Introduction : Bisphenol A (BPA) exposure has been correlated to non-alcoholic fatty liver disease (NAFLD) development and progression. We investigated, in a clinical model, the effects of the administration of 303 mg of silybin phospholipids complex, 10 μg of vitamin D, and 15 mg of vitamin E (RealSIL, 100D, IBI-Lorenzini, Aprilia, Italy) in male NAFLD patients exposed to BPA on metabolic, hormonal, and oxidative stress-related parameters. Methods : We enrolled 32 male patients with histologic diagnosis of NAFLD and treated them with Realsil 100D twice a day for six months. We performed at baseline clinical, biochemical, and food consumption assessments as well as the evaluation of physical exercise, thiobarbituric acid reactive substances (TBARS), plasmatic and urinary BPA and estrogen levels. The results obtained were compared with those of healthy control subjects and, in the NAFLD group, between baseline and the end of treatment. Results : A direct proportionality between TBARS levels and BPA exposure was shown ( p < 0.0001). The therapy determined a reduction of TBARS levels ( p = 0.011), an improvement of alanine aminotransferase, aspartate aminotransferase, insulinemia, homeostatic model assessment insulin resistance, C reactive protein, tumor necrosis factor alpha ( p < 0.05), an increase of conjugated BPA urine amount, and a reduction of its free form ( p < 0.0001; p = 0.0002). Moreover, the therapy caused an increase of plasmatic levels of the native form of estrogens ( p = 0.03). Conclusions : We highlighted the potential role of BPA in estrogen oxidation and oxidative stress in NAFLD patients. The use of Realsil 100D could contribute to fast BPA detoxification and to improve cellular antioxidant power, defending the integrity of biological estrogen-dependent pathways.

Keywords: non-alcoholic fatty liver disease; obesity; cancer biology; liver (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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