Sicca Symptoms, Oral Health Conditions, Salivary Flow and Oral Candida in Sjögren’s Syndrome Patients

Weini Xin, Katherine Chiu Man Leung, Edward Chin Man Lo, Mo Yin Mok and Moon Ho Leung
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Weini Xin: Department of Stomatology, Shantou University Medical College, Shantou 515041, China
Katherine Chiu Man Leung: Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong
Edward Chin Man Lo: Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong
Mo Yin Mok: Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong
Moon Ho Leung: Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, Hong Kong

IJERPH, 2020, vol. 17, issue 10, 1-11

Abstract: This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sjögren’s syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = 51.4) were recruited. They self-completed the Sicca Symptoms Inventory (SSI). Decayed, missing and filled surface (DMFS) scores, salivary flow rates, pH and oral Candida colonization were determined. Mean SSI summary scores of SS patients and non-SS individuals were 11.1 and 5.4 respectively ( p < 0.001). The most prevalent sicca symptoms in SS patients were eye irritation (93%), dry throat or nose (88%) and need of fluid for mouth wetting (88%). SS patients had significantly lower whole salivary flow rates than the non-SS individuals. Candida strains were isolated from over 60% of SS patients but not in non-SS patients. C. albicans was the predominant species. SSI summary score was negatively correlated to salivary flow rates while SSI summary and domain scores were positively correlated to the number of filled surfaces (FS) and DMFS scores and oral Candida counts. In conclusion, SS patients had more severe sicca symptoms than non-SS individuals. SSI scores were negatively correlated to the salivary flow rates but positively correlated to caries experience and oral Candida colonization.

Keywords: Sjögren’s syndrome; Sicca Symptoms Inventory; patient-reported outcomes; oral Candida (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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