Oral Microbiome of Children Living in an Isolated Area in Myanmar

Yoshiaki Nomura, Ryoko Otsuka, Ryo Hasegawa and Nobuhiro Hanada
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Yoshiaki Nomura: Department of Translational Research, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan
Ryoko Otsuka: Department of Translational Research, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan
Ryo Hasegawa: Department of Translational Research, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan
Nobuhiro Hanada: Department of Translational Research, Tsurumi University School of Dental Medicine, Yokohama 230-8501, Japan

IJERPH, 2020, vol. 17, issue 11, 1-11

Abstract: Several studies have shown that the oral microbiome is related to systemic health, and a co-relation with several specific diseases has been suggested. The oral microbiome depends on environmental- and community-level factors. In this observational study, the oral microbiomes of children of isolated mountain people were analyzed with respect to the core oral microbiome and etiology of dental caries. We collected samples of supragingival plaque from children (age 9–13) living in the Chin state of Myanmar. After DNA extraction and purification, next-generation sequencing of the V3–V4 hypervariable regions of the 16S rRNA was conducted. From thirteen subjects, 263,458 valid reads and 640 operational taxonomic units were generated at a 97% identity cut-off value. At the phylum level, Proteobacteria was the most abundant, followed by Firmicutes and Bacteroides . Forty-four bacteria were detected in total from all the subjects. For children without dental caries, Proteobacteria was abundant. In contrast, in children with dental caries, Firmicutes and Bacteroides were abundant. The oral microbiome of children living in an isolated area may be affected by environmental- and community-level factors. Additionally, the composition of the oral microbiome may affect the risk of dental caries.

Keywords: oral microbiome; dental caries; children (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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