Gestational Hypertension as Risk Factor of Hypertension in Middle-Aged and Older Women

Mariko Watanabe, Toshimi Sairenchi, Keiko Nishida, Koji Uchiyama, Yasuo Haruyama, Hiroshi Satonaka, Toshihiko Ishimitsu, Takanori Yasu, Ichio Fukasawa and Gen Kobashi
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Mariko Watanabe: Department of Obstetrics and Gynecology, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Toshimi Sairenchi: Department of Public Health, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Keiko Nishida: Department of Public Health, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Koji Uchiyama: Laboratory of International Environmental Health, Center for International Cooperation, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Yasuo Haruyama: Department of Public Health, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Hiroshi Satonaka: Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Toshihiko Ishimitsu: Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Takanori Yasu: Department of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, Nikko, Tochigi 321-2593, Japan
Ichio Fukasawa: Department of Obstetrics and Gynecology, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan
Gen Kobashi: Department of Public Health, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan

IJERPH, 2020, vol. 17, issue 11, 1-9

Abstract: The association of gestational hypertension (GH) with future hypertension in Japanese women is unclear. Hence, this study aimed to examine the association between GH and the risk of future hypertension in middle-aged-to-older Japanese women. A case-control study was performed, including 62 hypertensive women (case) and 75 nonhypertensive women (control). GH during the first pregnancy was diagnosed on the basis of the Maternal and Child Health Handbook record. Hypertensive women were recruited from outpatients in the hospital and residents who completed an annual health check-up in a community. Hypertension was defined as blood pressure with systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg, or taking antihypertensive medications. The average age (SD) of the cases and controls at the time of recruitment was 63.1 (8.4) and 57.7 (9.4), respectively. The multivariable-adjusted odds ratio of GH for hypertension in middle-aged-to-older women was 4.2 (95% confidence interval, 1.0–17.5) after adjustment for potential confounding factors such as age and body-mass index (BMI) upon recruitment, prepregnancy BMI, and age at first delivery. In conclusion, GH can be an independent risk factor for future hypertension among Japanese women.

Keywords: gestational hypertension; hypertensive disorders of pregnancy; hypertension; risk factor; cardiovascular disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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