Lethal Outcome of Leptospirosis in Southern Russia: Characterization of Leptospira Interrogans Isolated from a Deceased Teenager

Andrei E. Samoilov, Nataliya A. Stoyanova, Nikolai K. Tokarevich, Birgitta Evengard, Elena V. Zueva, Yulia A. Panferova, Yulia V. Ostankova, Elena B. Zueva, Diana E. Valutite, Evgeniy V. Kovalev, Anna R. Litovko, Alexey U. Goncharov, Alexandr V. Semenov, Kamil Khafizov and Vladimir G. Dedkov
Additional contact information
Andrei E. Samoilov: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Nataliya A. Stoyanova: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Nikolai K. Tokarevich: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Birgitta Evengard: Department of Clinical Microbiology, Umeå University, 90187 Umeå, Sweden
Elena V. Zueva: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Yulia A. Panferova: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Yulia V. Ostankova: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Elena B. Zueva: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Diana E. Valutite: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Evgeniy V. Kovalev: Department of Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance in the Rostov Region, 344019 Rostov-on-Don, Russia
Anna R. Litovko: Center for Hygiene and Epidemiology in the Rostov Region, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 344029 Rostov-on-Don, Russia
Alexey U. Goncharov: Center for Hygiene and Epidemiology in the Rostov Region, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 344029 Rostov-on-Don, Russia
Alexandr V. Semenov: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
Kamil Khafizov: Central Research Institute for Epidemiology, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 111123 Moscow, Russia
Vladimir G. Dedkov: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia

IJERPH, 2020, vol. 17, issue 12, 1-11

Abstract: This article describes a lethal case of leptospirosis that occurred in Southern Russia. The Leptospira strain was isolated and characterized using a microscopic agglutination test, MALDI-TOF mass spectrometry, targeted PCR, and high-throughput sequencing. We show that molecular and mass-spectrometry methods can be an alternative to conventional methods of leptospirosis diagnostics and Leptospira study, which require highly qualified staff and can be performed only at specialized laboratories. We also report the first whole genome of L . interrogans isolated in Russia.

Keywords: Leptospira; MALDI-TOF MS; PCR; high-throughput sequencing; MAT; Russia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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