Evidences from Clinical Trials in Down Syndrome: Diet, Exercise and Body Composition

Rosa María Martínez-Espinosa, Mariola D Molina Vila and Manuel Reig García-Galbis
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Rosa María Martínez-Espinosa: Division of Biochemistry and Molecular Biology, Department of Agrochemistry and Biochemistry, Faculty of Sciences, University of Alicante, 03690 Alicante, Spain
Mariola D Molina Vila: Applied Biochemistry Research Group AppBiochem, University of Alicante, 03690 Alicante, Spain
Manuel Reig García-Galbis: Applied Biochemistry Research Group AppBiochem, University of Alicante, 03690 Alicante, Spain

IJERPH, 2020, vol. 17, issue 12, 1-18

Abstract: Down syndrome (DS) is related to diseases like congenital heart disease, obstructive sleep apnea, obesity and overweight. Studies focused on DS associated with obesity and overweight are still scarce. The main objective of this work was to analyze the relationship between dietary intervention, physical exercise and body composition, in DS with overweight and obesity. This review is based on the PRISMA guidelines (Preferred Reporting Items for Systematic reviews and Meta-Analyses). Selection criteria for this analysis were: publications between January 1997 and December 2019; DS individuals with overweight and obesity; clinical trials using dietary intervention and physical exercise paying attention to changes in body composition. Selected clinical trials were focused on an exclusive intervention based on physical exercise. The anthropometric measures analyzed were body fat, BMI, waist circumference, body weight and fat free mass. The main conclusion is that prescribing structured physical exercise intervention may be related to a greater variation in body composition. Despite limited number of clinical trials analyzed, it can be assumed that the reported studies have not achieved optimal results and that the design of future clinical trials should be improved. Some guidelines are proposed to contribute to the improvement of knowledge in this field.

Keywords: Down’s syndrome; obesity; overweight; diet; exercise and body composition (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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