Sex Differences and the Influence of an Active Lifestyle on Adiposity in Patients with McArdle Disease

Irene Rodríguez-Gómez, Alfredo Santalla, Jorge Diez-Bermejo, Diego Munguía-Izquierdo, Luis M. Alegre, Gisela Nogales-Gadea, Joaquín Arenas, Miguel A. Martín, Alejandro Lucia and Ignacio Ara
Additional contact information
Irene Rodríguez-Gómez: GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain
Alfredo Santalla: CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain
Jorge Diez-Bermejo: Research Institute Hospital 12 de Octubre, 28041 Madrid, Spain
Diego Munguía-Izquierdo: CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain
Luis M. Alegre: GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain
Gisela Nogales-Gadea: Department of Neurosciences, Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol I Campus Can Ruti, Universitat Autònoma de Barcelona, 08041 Badalona, Spain
Joaquín Arenas: Research Institute Hospital 12 de Octubre, 28041 Madrid, Spain
Miguel A. Martín: Research Institute Hospital 12 de Octubre, 28041 Madrid, Spain
Alejandro Lucia: CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain
Ignacio Ara: GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain

IJERPH, 2020, vol. 17, issue 12, 1-11

Abstract: McArdle disease (glycogenosis-V) is associated with exercise intolerance, however, how it affects an important marker of cardiometabolic health as it is adiposity remains unknown. We evaluated the association between physical activity (PA) and adiposity in patients with McArdle disease. We assessed 199 adults of both sexes (51 McArdle patients (36 ± 11 years) and 148 healthy controls (35 ± 10 years)). Body fat (BF) was determined using dual-energy X-ray absorptiometry (DXA) method and each patient’s PA was assessed with the International PA Questionnaire (IPAQ). Although body mass index values did not differ between patients and controls, McArdle patients had significantly higher values of BF in all body regions ( p < 0.05) and higher risk of suffering obesity (odds ratio (OR): 2.54, 95% confidence interval (95% CI): 1.32–4.88). Male patients had higher BF and obesity risk (OR: 3.69, 95% CI: 1.46−9.34) than their sex-matched controls, but no differences were found within the female sex ( p < 0.05). In turn, active female patients had lower trunk BF than their inactive peers ( p < 0.05). Males with McArdle seem to have adiposity problems and a higher risk of developing obesity than people without the condition, while female patients show similar or even better levels in the trunk region with an active lifestyle. Therefore, special attention should be given to decrease adiposity and reduce obesity risk in males with McArdle disease.

Keywords: DXA; fat mass; exercise; physical activity; inactivity; obesity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/12/4334/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/12/4334/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:12:p:4334-:d:372750

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().