Modulation of Endothelial Glycocalyx and Microcirculation in Healthy Young Men during High-Intensity Sprint Interval Cycling-Exercise by Supplementation with Pomegranate Extract. A Randomized Controlled Trial

Zivile Pranskuniene, Egle Belousoviene, Neringa Baranauskiene, Nerijus Eimantas, Egle Vaitkaitiene, Jurga Bernatoniene, Marius Brazaitis and Andrius Pranskunas
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Zivile Pranskuniene: Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Sukileliu pr.13, LT-50162 Kaunas, Lithuania
Egle Belousoviene: Department of Intensive Care Medicine, Lithuanian University of Health Sciences, Eiveniu g. 2, LT-50161 Kaunas, Lithuania
Neringa Baranauskiene: Institute of Sport Science and Innovation, Lithuanian Sports University, Sporto g. 6, LT-44221 Kaunas, Lithuania
Nerijus Eimantas: Institute of Sport Science and Innovation, Lithuanian Sports University, Sporto g. 6, LT-44221 Kaunas, Lithuania
Egle Vaitkaitiene: Department of Disaster Medicine and Health Research Institute, Lithuanian University of Health Sciences, Eiveniu g. 4, LT-50161 Kaunas, Lithuania
Jurga Bernatoniene: Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Sukileliu pr.13, LT-50162 Kaunas, Lithuania
Marius Brazaitis: Institute of Sport Science and Innovation, Lithuanian Sports University, Sporto g. 6, LT-44221 Kaunas, Lithuania
Andrius Pranskunas: Department of Intensive Care Medicine, Lithuanian University of Health Sciences, Eiveniu g. 2, LT-50161 Kaunas, Lithuania

IJERPH, 2020, vol. 17, issue 12, 1-13

Abstract: The natural components of the pomegranate fruit may provide additional benefits for endothelial function and microcirculation. It was hypothesized that supplementation with pomegranate extract might improve glycocalyx properties and microcirculation during acute high-intensity sprint interval cycling exercise. Eighteen healthy and recreationally active male volunteers 22–28 years of age were recruited randomly to the experimental and control groups. The experimental group was supplemented with pomegranate extract 20 mL (720 mg phenolic compounds) for two weeks. At the beginning and end of the study, the participants completed a high-intensity sprint interval cycling-exercise protocol. The microcirculation flow and density parameters, glycocalyx markers, systemic hemodynamics, lactate, and glucose concentration were evaluated before and after the initial and repeated (after 2 weeks supplementation) exercise bouts. There were no significant differences in the microcirculation or glycocalyx over the course of the study ( p < 0.05). The lactate concentration was significantly higher in both groups after the initial and repeated exercise bouts, and were significantly higher in the experimental group compared to the control group after the repeated bout: 13.2 (11.9–14.8) vs. 10.3 (9.3–12.7) mmol/L, p = 0.017. Two weeks of supplementation with pomegranate extract does not influence changes in the microcirculation and glycocalyx during acute high-intensity sprint interval cycling-exercise. Although an unexplained rise in blood lactate concentration was observed.

Keywords: microcirculation; glycocalyx; polyphenols; sprint exercise (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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