Association between Reflux Esophagitis Incidence and Palmar Hyperhidrosis

Chun-Gu Cheng, Wu-Chien Chien, Chia-Peng Yu, Chi-Hsiang Chung and Chun-An Cheng
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Chun-Gu Cheng: Department of Emergency Medicine, Taoyuan Armed Forces General Hospital, National Defense Medical Center, Taoyuan 32549, Taiwan
Wu-Chien Chien: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan
Chia-Peng Yu: School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
Chi-Hsiang Chung: Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
Chun-An Cheng: Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan

IJERPH, 2020, vol. 17, issue 12, 1-10

Abstract: The autonomic dysfunction in palmar hyperhidrosis (PH) includes not only sympathetic overactivity but also parasympathetic impairment. A decrease of parasympathetic tone has been noted in gastroesophageal reflux disease of neonates and adults. Patients with reflux esophagitis have a defective anti-reflux barrier. The association between reflux esophagitis and PH is deliberated in this article. The National Health Insurance Database in Taiwan was used. At first-time visits, PH patients were identified by the International Classification of Disease, 9th Revision, Clinical Modification disease code of 780.8 without endoscopic thoracic sympathectomy. Patients were matched by age and gender as control groups. The reflux esophagitis incidence was assessed using disease codes 530.11, 530.81, and 530.85. The factors related to reflux esophagitis were established by the Cox proportional regression model. The risk of reflux esophagitis in PH patients had a hazard ratio of 3.457 (95% confidence interval: 3.043–3.928) after adjustment of the other factors. We confirmed the association between reflux esophagitis and PH. Health care providers must be alerted to this relationship and other risk factors of reflux esophagitis to support suitable treatments to improve the quality of life of patients.

Keywords: parasympathetic withdrawal; reflux esophagitis; palmar hyperhidrosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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Citations: View citations in EconPapers (3)

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