Distribution of HPV Genotypes in Patients with a Diagnosis of Anal Cancer in an Italian Region

Narcisa Muresu, Giovanni Sotgiu, Laura Saderi, Illari Sechi, Antonio Cossu, Vincenzo Marras, Marta Meloni, Marianna Martinelli, Clementina Cocuzza, Francesco Tanda and Andrea Piana
Additional contact information
Narcisa Muresu: Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
Giovanni Sotgiu: Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
Laura Saderi: Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy
Illari Sechi: Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy
Antonio Cossu: Department of Medical, Surgical and Experimental Sciences, Surgical Pathology, University of Sassari, 07100 Sassari, Italy
Vincenzo Marras: Department of Medical, Surgical and Experimental Sciences, Surgical Pathology, University of Sassari, 07100 Sassari, Italy
Marta Meloni: Department of Medical, Surgical and Experimental Sciences, Surgical Pathology, University of Sassari, 07100 Sassari, Italy
Marianna Martinelli: Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy
Clementina Cocuzza: Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy
Francesco Tanda: Department of Medical, Surgical and Experimental Sciences, Surgical Pathology, University of Sassari, 07100 Sassari, Italy
Andrea Piana: Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy

IJERPH, 2020, vol. 17, issue 12, 1-9

Abstract: Objectives: Anal cancer is a rare disease. However, its incidence is increasing in some population groups. Infection caused by Human Papillomavirus (HPV) is strongly associated with the risk of anal cancer, whose variability depends on samples, histology, and HPV detection methods. The aim of the study was to assess prevalence and distribution of HPV genotypes in patients diagnosed with anal carcinoma. Methods : An observational, retrospective study was carried out in a tertiary care hospital in North Sardinia, Italy. Specimens of anal cancer diagnosed from 2002–2018 were selected. Demographic, epidemiological, and clinical variables were collected to assess their relationship with the occurrence of anal cancer. Results : The overall HPV positivity was 70.0% (21/30), with HPV-16 being the predominant genotype (~85%). The highest prevalence of anal cancer was in patients aged ≥55 years. HPV positivity was higher in women ( p -value > 0.05) and in moderately differentiated samples (G2) ( p -value < 0.05). p16 INK4a and E6-transcript positivity were found in 57% and 24% of the HPV positive samples, respectively. The OS (overall survival) showed a not statistically significant difference in prognosis between HPV positive sand negatives (10, 47.6%, vs. 4, 44.4%; p -value = 0.25). Conclusions : HPV-DNA and p16 INK4a positivity confirmed the role of HPV in anal carcinoma. Our findings could support the implementation and scale-up of HPV vaccination in males and females to decrease the incidence of HPV-associated cancers. Further studies are needed to better clarify the prognostic role of HPV/p16 status.

Keywords: HPV; anal cancer; epidemiology; p-16; E6-gene (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/12/4516/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/12/4516/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:12:p:4516-:d:375379

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().