Bone Metabolism in Patients Treated for Depression

Elżbieta Skowrońska-Jóźwiak, Piotr Gałecki, Ewa Głowacka, Cezary Wojtyła, Przemysław Biliński and Andrzej Lewiński
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Elżbieta Skowrońska-Jóźwiak: Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland
Piotr Gałecki: Department of Adult Psychiatry, Medical University of Lodz, 91-229 Lodz, Poland
Ewa Głowacka: Department of Laboratory Diagnostics, Polish Mother’s Memorial Hospital—Research Institute, 93-338 Lodz, Poland
Cezary Wojtyła: Department of Oncological Gynecology and Obstetrics, Center of Postgraduate Medical Education, 00-416 Warsaw, Poland
Przemysław Biliński: Faculty of Heath Sciences, State University of Applied Sciences, 62-800 Kalisz, Poland
Andrzej Lewiński: Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 93-338 Lodz, Poland

IJERPH, 2020, vol. 17, issue 13, 1-8

Abstract: Background: Depression and osteoporosis are severe public health problems. There are conflicting findings regarding the influence of depression on bone metabolism. The aim of the presented study was to compare bone turnover markers and vitamin D levels between patients treated for depression and healthy controls. Patients and Methods: We determined a concentration of osteocalcin, carboxy-terminal telopeptide of type I collagen (β-CTX), 25-hydroxyvitamin D (25OHD) and 1,25(OH) 2 D 3 in 99 patients, aged 46.9 ± 11 years, treated for depression, as well as in 45 healthy subjects. Depressive status was determined with the Hamilton Depression Scale (HDRS). Results: In patients treated for depression, we demonstrated significantly lower osteocalcin concentrations ( p < 0.03) and higher concentration of β-CTX (result on the border of significance; p = 0.08). Those relationship were stronger in women. The level of 25OHD and 1,25(OH) 2 D 3 did not differ significantly between the examined groups. We observed a negative correlation between the 25OHD and HDRS score after treatment in all patients treated for depression and in subgroups of women and subjects with recurrent depression. Conclusions: Our results indicate that depression is related to disturbances in bone metabolism, especially in women and patients with recurrent depression, suggesting its role in context of osteoporosis development.

Keywords: depression; bone markers; osteocalcin; ?-CTX; vitamin D (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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