Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model

Shiri Kuperman, Ram Efraty, Ina Arie, Arkadi Rahmanov, Marina Rahmanov Gavrielov, Matityahau Noff, Ron Fishel and Sandu Pitaru
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Shiri Kuperman: School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
Ram Efraty: Shamir Medical Center, Tel Aviv University, Tel Aviv 6997801, Israel
Ina Arie: School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
Arkadi Rahmanov: School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
Marina Rahmanov Gavrielov: School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
Matityahau Noff: Shamir Medical Center, Tel Aviv University, Tel Aviv 6997801, Israel
Ron Fishel: Kaplan Medical Center, Hebrew University of Jerusalem, Jerusalem 91905, Israel
Sandu Pitaru: School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel

IJERPH, 2020, vol. 17, issue 13, 1-10

Abstract: Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic ( db/db ) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response ( p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue ( p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.

Keywords: oral stem cells; diabetic wound healing model; wound healing; diabetic mice model (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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