Myostatin A55T Genotype is Associated with Strength Recovery Following Exercise-Induced Muscle Damage

Jooyoung Kim, Kwanghoon Park and Joohyung Lee
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Jooyoung Kim: Office of Academic Affairs, Konkuk University, Chungju-si 27478, Korea
Kwanghoon Park: Department of Sport, Health and Rehabilitation, College of Physical Education, Kookmin University, Seoul 02707, Korea
Joohyung Lee: Department of Sport, Health and Rehabilitation, College of Physical Education, Kookmin University, Seoul 02707, Korea

IJERPH, 2020, vol. 17, issue 13, 1-8

Abstract: Myostatin A55T genotype is one of the candidates showing inter-individual variation in skeletal muscle phenotypes. The aim of this study was to investigate the effect of the myostatin A55T genotype on markers of muscle damage after eccentric exercise. Forty-eight young, healthy male college students (age = 24.8 ± 2.2 years, height = 176.7 ± 5.3 cm, weight = 73.7 ± 8.3 kg) were enrolled in this study, and muscle damage was induced through 50 reps of maximal eccentric muscle contraction. As markers of muscle damage, maximal isometric strength (MIS), muscle soreness, creatine kinase (CK), and aspartate transaminase (AST) were measured. Myostatin A55T genotypes were classified into homozygous myostatin A55T allele (AA, n = 34, 72%), heterozygous myostatin A55T allele (AT, n = 13, 26%), and homozygous mutant carriers (TT, n = 1, 2%). After eccentric exercise, the subjects with heterozygous for AT showed markedly quicker MIS recovery compared to the AA group ( p = 0.042). However, there were no significant variations in muscle soreness ( p = 0.379), CK ( p = 0.955), and AST ( p = 0.706) among the groups. These results suggest that AT in myostatin A55T genotype may be associated with quicker strength recovery following exercise-induced muscle damage.

Keywords: eccentric exercise; genotype; muscle damage; myostatin; strength recovery (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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